Abstract
The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We propose a model (dog-on-a-lead model) to understand the principles behind and consequences of cell-specific remote DNA contacts and speculate that cell-specific genome topologies can cause variegated gene expression among otherwise identical cells.
Translated title of the contribution | Identical cells with different 3D genomes; cause and consequences? |
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Original language | Undefined/Unknown |
Pages (from-to) | 191-6 |
Number of pages | 6 |
Journal | Current Opinion in Genetics & Development |
Volume | 23 |
Issue number | 2 |
Publication status | Published - 2013 |