Identical cells with different 3D genomes; cause and consequences?

Translated title of the contribution: Identical cells with different 3D genomes; cause and consequences?

P.H.L. Krijger, W.L. de Laat

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The mammalian genome is folded into topological domains, chromosomal units that probably serve to spatially accommodate enhancer-promoter interactions and control gene expression levels across cell populations. Longer-range contacts beyond topological domains are also formed, but only in subpopulations of cells. We propose a model (dog-on-a-lead model) to understand the principles behind and consequences of cell-specific remote DNA contacts and speculate that cell-specific genome topologies can cause variegated gene expression among otherwise identical cells.
Translated title of the contributionIdentical cells with different 3D genomes; cause and consequences?
Original languageUndefined/Unknown
Pages (from-to)191-6
Number of pages6
JournalCurrent Opinion in Genetics & Development
Volume23
Issue number2
Publication statusPublished - 2013

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