Hypertension, stroke, and coronary heart disease in relatives of patients with subarachnoid hemorrhage

J. E.C. Bromberg*, Gabriel J.E. Rinkel, A. Algra, U. A.C. Van Den Berg, M. L.R. Tjin-A-Ton, J. Van Gijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)


Background and Purpose: First-degree relatives of patients with subarachnoid hemorrhage (SAH) have a three to seven times greater risk of SAIl than second-degree relatives and than the general population. If hypertension, which is in part genetically determined, contributes to this increased risk, the frequency of hypertension and its sequelae would be expected to be higher in first than in second-degree relatives of patients with SAH. Methods: We compared the reported frequency of hypertension, stroke, and coronary heart disease between 1290 first- and 3588 second- degree relatives of a prospective series of patients with SAH. Results: The relative risk adjusted for age and survival status in first-degree relatives was 2.3 (95% confidence interval [CI], 1.9 to 2.9) for hypertension, 1.8 (95% CI, 1.3 to 2.4) for stroke, and 1.9 (95% CI, 1.5 to 2.3) for coronary heart disease. Conclusions: Hypertension is a familial factor contributing to the risk of SAH. Hypertension should he sought and treated in first-degree relatives of patients with SAH to reduce the increased risk of cerebrovascular and cardiovascular diseases.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
Issue number1
Publication statusPublished - 1 Jan 1996


  • hereditary disease
  • hypertension
  • subarachnoid hemorrhage


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