Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

A Riecher-Rössler; J.K. Rybakowski; M O Pflueger; R. Beyrau; R S Kahn; P. Malik; W Wolfgang Fleischhacker

doi:10.1017/S0033291713000226

Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

A Riecher-Rössler, J.K. Rybakowski, M O Pflueger, R. Beyrau, R S Kahn, P. Malik, W Wolfgang Fleischhacker,

Brain

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).

METHOD: In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.

RESULTS: Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.

CONCLUSIONS: Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.

Original language	English
Pages (from-to)	2571-82
Number of pages	12
Journal	Psychological Medicine
Volume	43
Issue number	12
DOIs	https://doi.org/10.1017/S0033291713000226
Publication status	Published - Dec 2013

Keywords

Adolescent
Adult
Clinical Trials as Topic
Europe
Female
Humans
Hyperprolactinemia
Male
Prolactin
Psychotic Disorders
Sex Factors
Young Adult
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

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10.1017/S0033291713000226

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title = "Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis",

abstract = "BACKGROUND: Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).METHOD: In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.RESULTS: Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.CONCLUSIONS: Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.",

keywords = "Adolescent, Adult, Clinical Trials as Topic, Europe, Female, Humans, Hyperprolactinemia, Male, Prolactin, Psychotic Disorders, Sex Factors, Young Adult, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't",

author = "A Riecher-R{\"o}ssler and J.K. Rybakowski and Pflueger, {M O} and R. Beyrau and Kahn, {R S} and P. Malik and Fleischhacker, {W Wolfgang}",

year = "2013",

month = dec,

doi = "10.1017/S0033291713000226",

language = "English",

volume = "43",

pages = "2571--82",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

number = "12",

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TY - JOUR

T1 - Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

AU - Riecher-Rössler, A

AU - Rybakowski, J.K.

AU - Pflueger, M O

AU - Beyrau, R.

AU - Kahn, R S

AU - Malik, P.

AU - Fleischhacker, W Wolfgang

PY - 2013/12

Y1 - 2013/12

N2 - BACKGROUND: Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).METHOD: In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.RESULTS: Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.CONCLUSIONS: Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.

AB - BACKGROUND: Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs).METHOD: In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500.RESULTS: Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men.CONCLUSIONS: Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.

KW - Adolescent

KW - Adult

KW - Clinical Trials as Topic

KW - Europe

KW - Female

KW - Humans

KW - Hyperprolactinemia

KW - Male

KW - Prolactin

KW - Psychotic Disorders

KW - Sex Factors

KW - Young Adult

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1017/S0033291713000226

DO - 10.1017/S0033291713000226

M3 - Article

C2 - 23590895

SN - 0033-2917

VL - 43

SP - 2571

EP - 2582

JO - Psychological Medicine

JF - Psychological Medicine

IS - 12

ER -

Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

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