Hypereosinophilic syndrome in children

M. Van Grotel*, M. de Hoog, R. R. de Krijger, H. B. Beverloo, M. M. van den Heuvel-Eibrink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


Recently, according to the Hypereosinophilic Diseases Working Group of the International Eosinophil Society, six variants of hypereosinophilic syndrome have been proposed, i.e. (1) myeloproliferative, (2) lymphoproliferative, (3) idiopathic/undefined, (4) overlapping, (5) associated and (6) familial variant. Hypereosinophilic syndrome is a rare disorder in children and can occur at any age during childhood. Corticosteroids are the treatment of choice, whereas other treatment options are hydroxyurea, IFNα, imatinib, vincristine, mepolizumab. We present a fulminant fatal case of hypereosinophilic syndrome in a teenager with an initial presentation of an idiopathic thrombocytopenia (ITP) and present a narrative review of literature.

Original languageEnglish
Pages (from-to)1249-1254
Number of pages6
JournalLeukemia Research
Issue number10
Publication statusPublished - 1 Oct 2012


  • Hypereosinophilic syndrome (HES)
  • Multi-organ failure
  • Thrombocytopenia
  • Urticaria


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