Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

K. M. Holwerda; E. M. Bos; A. Rajakumar; C. Ris-Stalpers; M. G. Van Pampus; A. Timmer; J. J.H.M. Erwich; M. M. Faas; H. Van Goor; A. T. Lely

doi:10.1016/j.placenta.2012.02.014

Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

K. M. Holwerda^*, E. M. Bos, A. Rajakumar, C. Ris-Stalpers, M. G. Van Pampus, A. Timmer, J. J.H.M. Erwich, M. M. Faas, H. Van Goor, A. T. Lely

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H ₂S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H ₂S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H ₂S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H ₂S-production and may aid in the anti-angiogenic state.

Original language	English
Pages (from-to)	518-521
Number of pages	4
Journal	Placenta
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.placenta.2012.02.014
Publication status	Published - Jun 2012
Externally published	Yes

Keywords

Cysthationine-beta-synthase
Cysthationine-gamma-lyase
Endothelial dysfunction
Hydrogen sulfide
Preeclampsia

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10.1016/j.placenta.2012.02.014

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title = "Hydrogen sulfide producing enzymes in pregnancy and preeclampsia",

abstract = "Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H 2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H 2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H 2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H 2S-production and may aid in the anti-angiogenic state.",

keywords = "Cysthationine-beta-synthase, Cysthationine-gamma-lyase, Endothelial dysfunction, Hydrogen sulfide, Preeclampsia",

author = "Holwerda, {K. M.} and Bos, {E. M.} and A. Rajakumar and C. Ris-Stalpers and {Van Pampus}, {M. G.} and A. Timmer and Erwich, {J. J.H.M.} and Faas, {M. M.} and {Van Goor}, H. and Lely, {A. T.}",

note = "Funding Information: This work was supported by a grant from the Dutch Kidney Foundation ( KBSO 11.014 ), a Mandema Stipendium (to Dr. A.T. Lely) from the University Medical Center Groningen , and a grant from the Groningen University Institute of Drug Exploration . The authors greatly acknowledge the technical contribution of Sippie Huitema and Theo Borghuis, and the PREHAT-team for processing placental tissues. ",

year = "2012",

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doi = "10.1016/j.placenta.2012.02.014",

language = "English",

volume = "33",

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journal = "Placenta",

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AU - Holwerda, K. M.

AU - Bos, E. M.

AU - Rajakumar, A.

AU - Ris-Stalpers, C.

AU - Van Pampus, M. G.

AU - Timmer, A.

AU - Erwich, J. J.H.M.

AU - Faas, M. M.

AU - Van Goor, H.

AU - Lely, A. T.

N1 - Funding Information: This work was supported by a grant from the Dutch Kidney Foundation ( KBSO 11.014 ), a Mandema Stipendium (to Dr. A.T. Lely) from the University Medical Center Groningen , and a grant from the Groningen University Institute of Drug Exploration . The authors greatly acknowledge the technical contribution of Sippie Huitema and Theo Borghuis, and the PREHAT-team for processing placental tissues.

PY - 2012/6

Y1 - 2012/6

N2 - Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H 2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H 2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H 2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H 2S-production and may aid in the anti-angiogenic state.

AB - Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H 2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H 2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H 2S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H 2S-production and may aid in the anti-angiogenic state.

KW - Cysthationine-beta-synthase

KW - Cysthationine-gamma-lyase

KW - Endothelial dysfunction

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KW - Preeclampsia

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Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

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Keywords

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