TY - JOUR
T1 - Human tissues in a dish
T2 - The research and ethical implications of organoid technology
AU - Bredenoord, Annelien L.
AU - Clevers, Hans
AU - Knoblich, Juergen A.
N1 - Funding Information:
We are grateful to the members of our research groups for numerous discussions that led to the ideas expressed in this Review. J.A.K. thanks U. Körtner and C. Druml for insightful discussions on the ethics of organoid and human embryonic stem cell research. We also thank M. Lancaster, H. Gehart, and N. Sachs for providing images and T. Kulcsar for graphics support. The work of A.L.B. is supported by The Netherlands Organization for Health Research and Development (ZonMw, grant 731010020). Work in J.A.K.'s laboratory is supported by the Austrian Academy of Sciences, the Austrian Science Fund (grants I-1281-B19 and Z-153-B09), and an advanced grant from the European Research Council.
Publisher Copyright:
Copyright © 2016 by the American Association for the Advancement of Science.
PY - 2017/1/20
Y1 - 2017/1/20
N2 - The ability to generate human tissues in vitro from stem cells has raised enormous expectations among the biomedical research community, patients, and the general public. These organoids enable studies of normal development and disease and allow the testing of compounds directly on human tissue. Organoids hold the promise to influence the entire innovation cycle in biomedical research. They affect fields that have been subjects of intense ethical debate, ranging from animal experiments and the use of embryonic or fetal human tissues to precision medicine, organoid transplantation, and gene therapy. However, organoid research also raises additional ethical questions that require reexamination and potential recalibration of ethical and legal policies. In this Review, we describe the current state of research and discuss the ethical implications of organoid technology.
AB - The ability to generate human tissues in vitro from stem cells has raised enormous expectations among the biomedical research community, patients, and the general public. These organoids enable studies of normal development and disease and allow the testing of compounds directly on human tissue. Organoids hold the promise to influence the entire innovation cycle in biomedical research. They affect fields that have been subjects of intense ethical debate, ranging from animal experiments and the use of embryonic or fetal human tissues to precision medicine, organoid transplantation, and gene therapy. However, organoid research also raises additional ethical questions that require reexamination and potential recalibration of ethical and legal policies. In this Review, we describe the current state of research and discuss the ethical implications of organoid technology.
UR - http://www.scopus.com/inward/record.url?scp=85010637378&partnerID=8YFLogxK
U2 - 10.1126/science.aaf9414
DO - 10.1126/science.aaf9414
M3 - Article
C2 - 28104841
AN - SCOPUS:85010637378
SN - 0036-8075
VL - 355
JO - Science
JF - Science
IS - 6322
M1 - eaaf9414
ER -