Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: detection and prognostic significance

A C Ansink; M R Krul; R A De Weger; J A Kleyne; H Pijpers; H Van Tinteren; E W De Kraker; T J Helmerhorst; A P Heintz

doi:10.1006/gyno.1994.1028

Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: detection and prognostic significance

A C Ansink, M R Krul, R A De Weger, J A Kleyne, H Pijpers, H Van Tinteren, E W De Kraker, T J Helmerhorst, A P Heintz

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV-DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV-positive cancers, lichen sclerosus can be found.

Original language	English
Pages (from-to)	180-4
Number of pages	5
Journal	Gynecologic Oncology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1006/gyno.1994.1028
Publication status	Published - Feb 1994

Keywords

Base Sequence
Carcinoma, Squamous Cell
DNA, Viral
Female
Humans
Molecular Probes
Molecular Sequence Data
Papillomaviridae
Polymerase Chain Reaction
Prognosis
Skin Diseases
Survival Analysis
Vulvar Neoplasms

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10.1006/gyno.1994.1028

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title = "Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: detection and prognostic significance",

abstract = "Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV-DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV-positive cancers, lichen sclerosus can be found.",

keywords = "Base Sequence, Carcinoma, Squamous Cell, DNA, Viral, Female, Humans, Molecular Probes, Molecular Sequence Data, Papillomaviridae, Polymerase Chain Reaction, Prognosis, Skin Diseases, Survival Analysis, Vulvar Neoplasms",

author = "Ansink, {A C} and Krul, {M R} and {De Weger}, {R A} and Kleyne, {J A} and H Pijpers and {Van Tinteren}, H and {De Kraker}, {E W} and Helmerhorst, {T J} and Heintz, {A P}",

year = "1994",

month = feb,

doi = "10.1006/gyno.1994.1028",

language = "English",

volume = "52",

pages = "180--4",

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T1 - Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva

T2 - detection and prognostic significance

AU - Ansink, A C

AU - Krul, M R

AU - De Weger, R A

AU - Kleyne, J A

AU - Pijpers, H

AU - Van Tinteren, H

AU - De Kraker, E W

AU - Helmerhorst, T J

AU - Heintz, A P

PY - 1994/2

Y1 - 1994/2

N2 - Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV-DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV-positive cancers, lichen sclerosus can be found.

AB - Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV-DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV-positive cancers, lichen sclerosus can be found.

KW - Base Sequence

KW - Carcinoma, Squamous Cell

KW - DNA, Viral

KW - Female

KW - Humans

KW - Molecular Probes

KW - Molecular Sequence Data

KW - Papillomaviridae

KW - Polymerase Chain Reaction

KW - Prognosis

KW - Skin Diseases

KW - Survival Analysis

KW - Vulvar Neoplasms

U2 - 10.1006/gyno.1994.1028

DO - 10.1006/gyno.1994.1028

M3 - Article

C2 - 8314136

SN - 0090-8258

VL - 52

SP - 180

EP - 184

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva: detection and prognostic significance

Abstract

Keywords

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