Human neutrophil kinetics: a call to revisit old evidence

Leo Koenderman*, Kiki Tesselaar, Nienke Vrisekoop

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The half-life of human neutrophils is still controversial, with estimates ranging from 7–9 h to 3.75 days. This debate should be settled to understand neutrophil production in the bone marrow (BM) and the potential and limitations of emergency neutropoiesis following infection or trauma. Furthermore, cellular lifespan greatly influences the potential effect(s) neutrophils have on the adaptive immune response. We posit that blood neutrophils are in exchange with different tissues, but particularly the BM, as it contains the largest pool of mature neutrophils. Furthermore, we propose that the oldest neutrophils are the first to die following a so-called conveyor belt model. These guiding principles shed new light on our interpretation of existing neutrophil lifespan data and offer recommendations for future research.

Original languageEnglish
Pages (from-to)868-876
Number of pages9
JournalTrends in immunology
Volume43
Issue number11
Early online date12 Oct 2022
DOIs
Publication statusPublished - Nov 2022

Keywords

  • bone marrow
  • conveyor belt model
  • kinetics
  • labeling
  • lifespan
  • neutrophil
  • Adaptive Immunity
  • Bone Marrow Cells
  • Humans
  • Neutrophils
  • Kinetics
  • Bone Marrow

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