TY - JOUR
T1 - Human Immunodeficiency Virus-2 (HIV-2)
T2 - A Summary of the Present Standard of Care and Treatment Options for Individuals Living with HIV-2 in Western Europe
AU - Berzow, Dirk
AU - Descamps, Diane
AU - Obermeier, Martin
AU - Charpentier, Charlotte
AU - Kaiser, Rolf
AU - Guertler, Lutz
AU - Eberle, Josef
AU - Wensing, Annemarie
AU - Sierra, Saleta
AU - Ruelle, Jean
AU - Gomes, Perpetua
AU - Mansinho, Kamal
AU - Taylor, Ninon
AU - Jensen, Björn
AU - Döring, Matthias
AU - Stürmer, Martin
AU - Rockstroh, Jürgen
AU - Camacho, Ricardo
N1 - Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living with HIV-2 in Europe. Compared to HIV-1, there are differential characteristics of HIV-2 regarding diagnostic procedures, the clinical course, and, most importantly, antiretroviral therapy. We integrated the published literature on HIV-2 (studies and reports on epidemiology, diagnostics, the clinical course, and treatment), as well as expert experience in diagnosing and clinical care, to provide recommendations for a present standard of medical care of those living with HIV-2 in Western European countries, including an overview of strategies for diagnosis, monitoring, and treatment, with suggestions for effective drug combinations for first- and second-line treatments, post-exposure prophylaxis, and the prevention of mother-to-child transmission, as well as listings of mutations related to HIV-2 drug resistance and C-C motif chemokine receptor type 5 and C-X-C motif chemokine receptor type 4 coreceptor tropism.
AB - Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living with HIV-2 in Europe. Compared to HIV-1, there are differential characteristics of HIV-2 regarding diagnostic procedures, the clinical course, and, most importantly, antiretroviral therapy. We integrated the published literature on HIV-2 (studies and reports on epidemiology, diagnostics, the clinical course, and treatment), as well as expert experience in diagnosing and clinical care, to provide recommendations for a present standard of medical care of those living with HIV-2 in Western European countries, including an overview of strategies for diagnosis, monitoring, and treatment, with suggestions for effective drug combinations for first- and second-line treatments, post-exposure prophylaxis, and the prevention of mother-to-child transmission, as well as listings of mutations related to HIV-2 drug resistance and C-C motif chemokine receptor type 5 and C-X-C motif chemokine receptor type 4 coreceptor tropism.
KW - antiretroviral therapy
KW - care
KW - diagnosis
KW - HIV-2
KW - resistance
KW - Standard of Care
KW - Europe
KW - Humans
KW - Anti-HIV Agents/therapeutic use
KW - Infectious Disease Transmission, Vertical
KW - HIV Infections/diagnosis
KW - Female
KW - Child
KW - Africa, Western
KW - HIV-2/genetics
UR - https://www.scopus.com/pages/publications/85102212685
U2 - 10.1093/cid/ciaa275
DO - 10.1093/cid/ciaa275
M3 - Article
C2 - 32227124
AN - SCOPUS:85102212685
SN - 1058-4838
VL - 72
SP - 503
EP - 509
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -