Human enteroids: preclinical models of non-inflammatory diarrhea

Olga Kovbasnjuk, Nicholas C. Zachos, Julie In, Jennifer Foulke-Abel, Khalil Ettayebi, Joseph M. Hyser, James R. Broughman, Xi-Lei Zeng, Sabine Middendorp, Hugo R. de Jonge, Mary K. Estes*, Mark Donowitz

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to off er an enhanced platform for developing drug therapy. Our work employs human enteroids derived from each of the major intestinal sections to advance understanding of several diarrheal diseases, including those caused by cholera, rotavirus and enterohemorrhagic Escherichia coli. An enteroid bank is being established to facilitate comparison of segmental, developmental, and regulatory differences in transport proteins that can influence therapy efficacy. Basic characterization of major ion transport protein expression, localization and function in the human enteroid model sets the stage to study the effects of enteric infection at the transport level, as well as to monitor potential responses to pharmacological intervention.

Original languageEnglish
Article number3
Number of pages4
JournalStem Cell Research & Therapy [E]
Volume4
DOIs
Publication statusPublished - 20 Dec 2013

Keywords

  • ENTERIC NERVOUS-SYSTEM
  • STEM-CELLS
  • IN-VITRO
  • SECRETION
  • EPITHELIUM
  • EXPANSION
  • ORGANOIDS
  • FLUID
  • COLON
  • LGR5

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