HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

S.H. Mooij; O. Landén; F.R.M. van der Klis; M.A.B. van der Sande; H.E. de Melker; M. Xiridou; R.A. Coutinho; A. van Eeden; R.L.J. Heijman; A.G.C.L. Speksnijder; P.J.F. Snijders; M.F. Schim van der Loeff

doi:10.1158/1055-9965.EPI-14-0199

HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

S.H. Mooij, O. Landén, F.R.M. van der Klis, M.A.B. van der Sande, H.E. de Melker, M. Xiridou, R.A. Coutinho, A. van Eeden, R.L.J. Heijman, A.G.C.L. Speksnijder, P.J.F. Snijders, M.F. Schim van der Loeff

Julius Center, dept. Epidemiology & Health Economics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).

METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.

RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).

CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.

IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

Original language	English
Pages (from-to)	2455-2461
Number of pages	7
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	23
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-0199
Publication status	Published - Nov 2014

Keywords

Adult
Anal Canal
HIV Infections
Homosexuality, Male
Humans
Male
Papillomaviridae
Papillomavirus Infections
Penis
Risk Factors

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10.1158/1055-9965.EPI-14-0199

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Mooij, S. H., Landén, O., van der Klis, F. R. M., van der Sande, M. A. B., de Melker, H. E., Xiridou, M., Coutinho, R. A., van Eeden, A., Heijman, R. L. J., Speksnijder, A. G. C. L., Snijders, P. J. F., & Schim van der Loeff, M. F. (2014). HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM. Cancer Epidemiology Biomarkers & Prevention, 23(11), 2455-2461. https://doi.org/10.1158/1055-9965.EPI-14-0199

@article{ec3a37a3ade541168b2ec2f9c28800e2,

title = "HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM",

abstract = "BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.",

keywords = "Adult, Anal Canal, HIV Infections, Homosexuality, Male, Humans, Male, Papillomaviridae, Papillomavirus Infections, Penis, Risk Factors",

author = "S.H. Mooij and O. Land{\'e}n and {van der Klis}, F.R.M. and {van der Sande}, M.A.B. and {de Melker}, H.E. and M. Xiridou and R.A. Coutinho and {van Eeden}, A. and R.L.J. Heijman and A.G.C.L. Speksnijder and P.J.F. Snijders and {Schim van der Loeff}, M.F.",

note = "{\textcopyright}2014 American Association for Cancer Research.",

year = "2014",

month = nov,

doi = "10.1158/1055-9965.EPI-14-0199",

language = "English",

volume = "23",

pages = "2455--2461",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "11",

}

Mooij, SH, Landén, O, van der Klis, FRM, van der Sande, MAB, de Melker, HE, Xiridou, M, Coutinho, RA, van Eeden, A, Heijman, RLJ, Speksnijder, AGCL, Snijders, PJF & Schim van der Loeff, MF 2014, 'HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM', Cancer Epidemiology Biomarkers & Prevention, vol. 23, no. 11, pp. 2455-2461. https://doi.org/10.1158/1055-9965.EPI-14-0199

TY - JOUR

T1 - HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

AU - Mooij, S.H.

AU - Landén, O.

AU - van der Klis, F.R.M.

AU - van der Sande, M.A.B.

AU - de Melker, H.E.

AU - Xiridou, M.

AU - Coutinho, R.A.

AU - van Eeden, A.

AU - Heijman, R.L.J.

AU - Speksnijder, A.G.C.L.

AU - Snijders, P.J.F.

AU - Schim van der Loeff, M.F.

PY - 2014/11

Y1 - 2014/11

N2 - BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

AB - BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

KW - Adult

KW - Anal Canal

KW - HIV Infections

KW - Homosexuality, Male

KW - Humans

KW - Male

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Penis

KW - Risk Factors

U2 - 10.1158/1055-9965.EPI-14-0199

DO - 10.1158/1055-9965.EPI-14-0199

M3 - Article

C2 - 25169974

SN - 1055-9965

VL - 23

SP - 2455

EP - 2461

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 11

ER -

HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

Abstract

Keywords

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