How to quantify information loss due to phase ambiguity in haplotype case-control studies

HW Uh; Jeanine J. Houwing-Duistermaat; Hein Putter; Hans C. Van Houwelingen

doi:10.1186/1471-2156-6-S1-S108

How to quantify information loss due to phase ambiguity in haplotype case-control studies

HW Uh, Jeanine J. Houwing-Duistermaat, Hein Putter, Hans C. Van Houwelingen

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information.

Original language	English
Article number	S108
Journal	BMC Genetics
Volume	6
Issue number	SUPPL.1
DOIs	https://doi.org/10.1186/1471-2156-6-S1-S108
Publication status	Published - 30 Dec 2005

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https://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156-6-S1-S108

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title = "How to quantify information loss due to phase ambiguity in haplotype case-control studies",

abstract = "Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information.",

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AU - Van Houwelingen, Hans C.

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AB - Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information.

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JO - BMC Genetics

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How to quantify information loss due to phase ambiguity in haplotype case-control studies

Abstract

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