Abstract
IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.
Original language | English |
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Article number | 108538 |
Number of pages | 8 |
Journal | Clinical Immunology |
Volume | 219 |
DOIs | |
Publication status | Published - Oct 2020 |
Keywords
- Auto-immune inflammation
- Auto-inflammation
- Mechanisms of disease