How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

N. M. ter Haar; M. H.A. Jansen; J. F. Frenkel; S. J. Vastert

doi:10.1016/j.clim.2020.108538

How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

N. M. ter Haar, M. H.A. Jansen, J. F. Frenkel, S. J. Vastert^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.

Original language	English
Article number	108538
Number of pages	8
Journal	Clinical Immunology
Volume	219
DOIs	https://doi.org/10.1016/j.clim.2020.108538
Publication status	Published - Oct 2020

Keywords

Auto-immune inflammation
Auto-inflammation
Mechanisms of disease

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10.1016/j.clim.2020.108538

1-s2.0-S152166161930628X-mainFinal published version, 303 KBLicence: CC BY

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title = "How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases",

abstract = "IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.",

keywords = "Auto-immune inflammation, Auto-inflammation, Mechanisms of disease",

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AU - Jansen, M. H.A.

AU - Frenkel, J. F.

AU - Vastert, S. J.

PY - 2020/10

Y1 - 2020/10

N2 - IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.

AB - IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.

KW - Auto-immune inflammation

KW - Auto-inflammation

KW - Mechanisms of disease

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JO - Clinical Immunology

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ER -

How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

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Keywords

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