TY - JOUR
T1 - Hormone replacement in survivors of childhood cancer and brain tumors
T2 - safety and controversies
AU - van Roessel, Ichelle M A A
AU - Bakker, Boudewijn
AU - van Santen, Hanneke M
AU - Chemaitilly, Wassim
PY - 2022/12/13
Y1 - 2022/12/13
N2 - Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This manuscript offers a summary of current knowledge, controversies and areas for future research pertaining to this area.
AB - Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This manuscript offers a summary of current knowledge, controversies and areas for future research pertaining to this area.
KW - childhood cancer
KW - childhood brain tumors
KW - growth hormone
KW - hypothyroidism
KW - hypogonadism
U2 - 10.1530/EC-22-0382
DO - 10.1530/EC-22-0382
M3 - Review article
C2 - 36347051
SN - 2049-3614
VL - 12
JO - Endocrine connections
JF - Endocrine connections
IS - 1
ER -