Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

Rose-Anne Lavergne; Taieb Chouaki; Ferry Hagen; Bénédicte Toublanc; Hervé Dupont; Vincent Jounieaux; Jacques F Meis; Florent Morio; Patrice Le Pape

doi:10.1093/cid/ciw664

Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

Rose-Anne Lavergne
, Taieb Chouaki
, Ferry Hagen
, Bénédicte Toublanc
, Hervé Dupont
, Vincent Jounieaux
, Jacques F Meis
, Florent Morio
, Patrice Le Pape^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.

Original language	English
Pages (from-to)	76-78
Number of pages	3
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	64
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciw664
Publication status	Published - 1 Jan 2017
Externally published	Yes

Keywords

Aged
Antifungal Agents/pharmacology
Arthritis, Rheumatoid/complications
Aspergillosis/drug therapy
Aspergillus fumigatus/drug effects
Azoles/pharmacology
Cytochrome P-450 Enzyme System/genetics
Drug Resistance, Fungal
Fatal Outcome
Fungal Proteins/genetics
Humans
Immunocompromised Host
Infliximab/adverse effects
Microbial Sensitivity Tests
Mutation

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10.1093/cid/ciw664

Cite this

Lavergne, R.-A., Chouaki, T., Hagen, F., Toublanc, B., Dupont, H., Jounieaux, V., Meis, J. F., Morio, F., & Le Pape, P. (2017). Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 64(1), 76-78. https://doi.org/10.1093/cid/ciw664

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title = "Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients",

abstract = "A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.",

keywords = "Aged, Antifungal Agents/pharmacology, Arthritis, Rheumatoid/complications, Aspergillosis/drug therapy, Aspergillus fumigatus/drug effects, Azoles/pharmacology, Cytochrome P-450 Enzyme System/genetics, Drug Resistance, Fungal, Fatal Outcome, Fungal Proteins/genetics, Humans, Immunocompromised Host, Infliximab/adverse effects, Microbial Sensitivity Tests, Mutation",

author = "Rose-Anne Lavergne and Taieb Chouaki and Ferry Hagen and B{\'e}n{\'e}dicte Toublanc and Herv{\'e} Dupont and Vincent Jounieaux and Meis, \{Jacques F\} and Florent Morio and \{Le Pape\}, Patrice",

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month = jan,

day = "1",

doi = "10.1093/cid/ciw664",

language = "English",

volume = "64",

pages = "76--78",

journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",

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Lavergne, R-A, Chouaki, T, Hagen, F, Toublanc, B, Dupont, H, Jounieaux, V, Meis, JF, Morio, F & Le Pape, P 2017, 'Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 64, no. 1, pp. 76-78. https://doi.org/10.1093/cid/ciw664

Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients. / Lavergne, Rose-Anne; Chouaki, Taieb; Hagen, Ferry et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 64, No. 1, 01.01.2017, p. 76-78.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

AU - Lavergne, Rose-Anne

AU - Chouaki, Taieb

AU - Hagen, Ferry

AU - Toublanc, Bénédicte

AU - Dupont, Hervé

AU - Jounieaux, Vincent

AU - Meis, Jacques F

AU - Morio, Florent

AU - Le Pape, Patrice

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.

AB - A case of fatal aspergillosis due to a TR46/Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.

KW - Aged

KW - Antifungal Agents/pharmacology

KW - Arthritis, Rheumatoid/complications

KW - Aspergillosis/drug therapy

KW - Aspergillus fumigatus/drug effects

KW - Azoles/pharmacology

KW - Cytochrome P-450 Enzyme System/genetics

KW - Drug Resistance, Fungal

KW - Fatal Outcome

KW - Fungal Proteins/genetics

KW - Humans

KW - Immunocompromised Host

KW - Infliximab/adverse effects

KW - Microbial Sensitivity Tests

KW - Mutation

U2 - 10.1093/cid/ciw664

DO - 10.1093/cid/ciw664

M3 - Article

C2 - 27682064

SN - 1058-4838

VL - 64

SP - 76

EP - 78

JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

IS - 1

ER -

Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients

Abstract

Keywords

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