HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates

  • T. F.W. Wolfs
  • , C. Breederveld
  • , W. J.A. Krone
  • , V. D.L. Hoek
  • , M. Bakker
  • , L. Smit
  • , J. Goudsmit
  • , L. J. Bosch
  • , E. Briet
  • , W. Gerrits
  • , A. C.J.M. Holdrinet
  • , E. P. Mauser-Bunschoten
  • , V. D.J. Meer
  • , J. Novakova
  • , V. D.J.A. Snoek
  • , J. Stibbe

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

A national multicentre study was performed to investigate the effects of donorselecion and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.

Original languageEnglish
Pages (from-to)396-399
Number of pages4
JournalThrombosis and Haemostasis
Volume59
Issue number3
Publication statusPublished - 1 Jan 1988

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