HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates

T. F.W. Wolfs; C. Breederveld; W. J.A. Krone; V. D.L. Hoek; M. Bakker; L. Smit; J. Goudsmit; L. J. Bosch; E. Briet; W. Gerrits; A. C.J.M. Holdrinet; E. P. Mauser-Bunschoten; V. D.J. Meer; J. Novakova; V. D.J.A. Snoek; J. Stibbe

HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates

T. F.W. Wolfs, C. Breederveld, W. J.A. Krone, V. D.L. Hoek, M. Bakker, L. Smit, J. Goudsmit, L. J. Bosch, E. Briet, W. Gerrits, A. C.J.M. Holdrinet, E. P. Mauser-Bunschoten, V. D.J. Meer, J. Novakova, V. D.J.A. Snoek, J. Stibbe

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A national multicentre study was performed to investigate the effects of donorselecion and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.

Original language	English
Pages (from-to)	396-399
Number of pages	4
Journal	Thrombosis and Haemostasis
Volume	59
Issue number	3
Publication status	Published - 1 Jan 1988

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Wolfs, T. F. W., Breederveld, C., Krone, W. J. A., Hoek, V. D. L., Bakker, M., Smit, L., Goudsmit, J., Bosch, L. J., Briet, E., Gerrits, W., Holdrinet, A. C. J. M., Mauser-Bunschoten, E. P., Meer, V. D. J., Novakova, J., Snoek, V. D. J. A., & Stibbe, J. (1988). HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates. Thrombosis and Haemostasis, 59(3), 396-399.

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title = "HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates",

abstract = "A national multicentre study was performed to investigate the effects of donorselecion and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.",

author = "Wolfs, {T. F.W.} and C. Breederveld and Krone, {W. J.A.} and Hoek, {V. D.L.} and M. Bakker and L. Smit and J. Goudsmit and Bosch, {L. J.} and E. Briet and W. Gerrits and Holdrinet, {A. C.J.M.} and Mauser-Bunschoten, {E. P.} and Meer, {V. D.J.} and J. Novakova and Snoek, {V. D.J.A.} and J. Stibbe",

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Wolfs, TFW, Breederveld, C, Krone, WJA, Hoek, VDL, Bakker, M, Smit, L, Goudsmit, J, Bosch, LJ, Briet, E, Gerrits, W, Holdrinet, ACJM, Mauser-Bunschoten, EP, Meer, VDJ, Novakova, J, Snoek, VDJA & Stibbe, J 1988, 'HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates', Thrombosis and Haemostasis, vol. 59, no. 3, pp. 396-399.

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T1 - HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates

AU - Wolfs, T. F.W.

AU - Breederveld, C.

AU - Krone, W. J.A.

AU - Hoek, V. D.L.

AU - Bakker, M.

AU - Smit, L.

AU - Goudsmit, J.

AU - Bosch, L. J.

AU - Briet, E.

AU - Gerrits, W.

AU - Holdrinet, A. C.J.M.

AU - Mauser-Bunschoten, E. P.

AU - Meer, V. D.J.

AU - Novakova, J.

AU - Snoek, V. D.J.A.

AU - Stibbe, J.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - A national multicentre study was performed to investigate the effects of donorselecion and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.

AB - A national multicentre study was performed to investigate the effects of donorselecion and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983 and 1986. Nineteen of 20 seroconversions could be related to the use of non heat-treated products in the year preceding HIV antibody seroconversion. One seroconversion occurred in a person using heat-treated non donor screened product. Seroconversion rate decreased as a result of the policy to discourage high risk blood donors and no seroconversions were observed following the introduction of donor screening in 1985.

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AN - SCOPUS:0023878538

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JF - Thrombosis and Haemostasis

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ER -

HIV-antibody seroconversions in Dutch haemophiliacs using heat-treated and non heat-treated coagulation factor concentrates

Abstract

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