Hippocampal insulin resistance and cognitive dysfunction

Geert Jan Biessels, Lawrence P. Reagan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.

Original languageEnglish
Pages (from-to)660-671
Number of pages12
JournalNature Reviews Neuroscience
Volume16
Issue number11
DOIs
Publication statusPublished - 1 Nov 2015

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