Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness

Loes Mandigers; Corstiaan A den Uil; Mirko Belliato; Hannelore Raemen; Eleonora Rossi; Joost van Rosmalen; Wim J R Rietdijk; Joo-Ree Melis; Diederik Gommers; Robert J van Thiel; Dinis Dos Reis Miranda

doi:10.1111/aor.14548

Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness

Loes Mandigers^*, Corstiaan A den Uil, Mirko Belliato, Hannelore Raemen, Eleonora Rossi, Joost van Rosmalen, Wim J R Rietdijk, Joo-Ree Melis, Diederik Gommers, Robert J van Thiel, Dinis Dos Reis Miranda

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: In cardiac arrest, cerebral ischemia and reperfusion injury mainly determine the neurological outcome. The aim of this study was to investigate the relation between the course of cerebral oxygenation and regain of consciousness in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR). We hypothesized that rapid cerebral oxygenation increase causes unfavorable outcomes.

METHODS: This prospective observational study was conducted in three European hospitals. We included adult ECPR patients between October 2018 and March 2020, in whom cerebral regional oxygen saturation (rSO2 ) measurements were started minutes before ECPR initiation until 3 h after. The primary outcome was regain of consciousness, defined as following commands, analyzed using binary logistic regression.

RESULTS: The sample consisted of 26 ECPR patients (23% women, Agemean 46 years). We found no significant differences in rSO2 values at baseline (49.1% versus 49.3% for regain versus no regain of consciousness). Mean cerebral rSO2 values in the first 30 min after ECPR initiation were higher in patients who regained consciousness (38%) than in patients who did not regain consciousness (62%, odds ratio 1.23, 95% confidence interval 1.01-1.50).

CONCLUSION: Higher mean cerebral rSO2 values in the first 30 min after initiation of ECPR were found in patients who regained consciousness.

Original language	English
Pages (from-to)	1479-1489
Number of pages	11
Journal	Artificial Organs
Volume	47
Issue number	9
DOIs	https://doi.org/10.1111/aor.14548
Publication status	Published - Sept 2023
Externally published	Yes

Keywords

Adult
Brain Ischemia/etiology
Cardiopulmonary Resuscitation/adverse effects
Consciousness
Female
Heart Arrest/complications
Humans
Male
Middle Aged
Out-of-Hospital Cardiac Arrest/therapy
Oxygen Saturation
Retrospective Studies

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10.1111/aor.14548Licence: CC BY

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Mandigers, L., den Uil, C. A., Belliato, M., Raemen, H., Rossi, E., van Rosmalen, J., Rietdijk, W. J. R., Melis, J.-R., Gommers, D., van Thiel, R. J., & Dos Reis Miranda, D. (2023). Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness. Artificial Organs, 47(9), 1479-1489. https://doi.org/10.1111/aor.14548

@article{870c46d1cc5e418a991e3536d401b48d,

title = "Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness",

abstract = "INTRODUCTION: In cardiac arrest, cerebral ischemia and reperfusion injury mainly determine the neurological outcome. The aim of this study was to investigate the relation between the course of cerebral oxygenation and regain of consciousness in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR). We hypothesized that rapid cerebral oxygenation increase causes unfavorable outcomes.METHODS: This prospective observational study was conducted in three European hospitals. We included adult ECPR patients between October 2018 and March 2020, in whom cerebral regional oxygen saturation (rSO2 ) measurements were started minutes before ECPR initiation until 3 h after. The primary outcome was regain of consciousness, defined as following commands, analyzed using binary logistic regression.RESULTS: The sample consisted of 26 ECPR patients (23% women, Agemean 46 years). We found no significant differences in rSO2 values at baseline (49.1% versus 49.3% for regain versus no regain of consciousness). Mean cerebral rSO2 values in the first 30 min after ECPR initiation were higher in patients who regained consciousness (38%) than in patients who did not regain consciousness (62%, odds ratio 1.23, 95% confidence interval 1.01-1.50).CONCLUSION: Higher mean cerebral rSO2 values in the first 30 min after initiation of ECPR were found in patients who regained consciousness.",

keywords = "Adult, Brain Ischemia/etiology, Cardiopulmonary Resuscitation/adverse effects, Consciousness, Female, Heart Arrest/complications, Humans, Male, Middle Aged, Out-of-Hospital Cardiac Arrest/therapy, Oxygen Saturation, Retrospective Studies",

author = "Loes Mandigers and {den Uil}, {Corstiaan A} and Mirko Belliato and Hannelore Raemen and Eleonora Rossi and {van Rosmalen}, Joost and Rietdijk, {Wim J R} and Joo-Ree Melis and Diederik Gommers and {van Thiel}, {Robert J} and {Dos Reis Miranda}, Dinis",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.",

year = "2023",

month = sep,

doi = "10.1111/aor.14548",

language = "English",

volume = "47",

pages = "1479--1489",

journal = "Artificial Organs",

issn = "0160-564X",

publisher = "Wiley-Blackwell",

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Mandigers, L, den Uil, CA, Belliato, M, Raemen, H, Rossi, E, van Rosmalen, J, Rietdijk, WJR, Melis, J-R, Gommers, D, van Thiel, RJ & Dos Reis Miranda, D 2023, 'Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness', Artificial Organs, vol. 47, no. 9, pp. 1479-1489. https://doi.org/10.1111/aor.14548

TY - JOUR

T1 - Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness

AU - Mandigers, Loes

AU - den Uil, Corstiaan A

AU - Belliato, Mirko

AU - Raemen, Hannelore

AU - Rossi, Eleonora

AU - van Rosmalen, Joost

AU - Rietdijk, Wim J R

AU - Melis, Joo-Ree

AU - Gommers, Diederik

AU - van Thiel, Robert J

AU - Dos Reis Miranda, Dinis

PY - 2023/9

Y1 - 2023/9

N2 - INTRODUCTION: In cardiac arrest, cerebral ischemia and reperfusion injury mainly determine the neurological outcome. The aim of this study was to investigate the relation between the course of cerebral oxygenation and regain of consciousness in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR). We hypothesized that rapid cerebral oxygenation increase causes unfavorable outcomes.METHODS: This prospective observational study was conducted in three European hospitals. We included adult ECPR patients between October 2018 and March 2020, in whom cerebral regional oxygen saturation (rSO2 ) measurements were started minutes before ECPR initiation until 3 h after. The primary outcome was regain of consciousness, defined as following commands, analyzed using binary logistic regression.RESULTS: The sample consisted of 26 ECPR patients (23% women, Agemean 46 years). We found no significant differences in rSO2 values at baseline (49.1% versus 49.3% for regain versus no regain of consciousness). Mean cerebral rSO2 values in the first 30 min after ECPR initiation were higher in patients who regained consciousness (38%) than in patients who did not regain consciousness (62%, odds ratio 1.23, 95% confidence interval 1.01-1.50).CONCLUSION: Higher mean cerebral rSO2 values in the first 30 min after initiation of ECPR were found in patients who regained consciousness.

AB - INTRODUCTION: In cardiac arrest, cerebral ischemia and reperfusion injury mainly determine the neurological outcome. The aim of this study was to investigate the relation between the course of cerebral oxygenation and regain of consciousness in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR). We hypothesized that rapid cerebral oxygenation increase causes unfavorable outcomes.METHODS: This prospective observational study was conducted in three European hospitals. We included adult ECPR patients between October 2018 and March 2020, in whom cerebral regional oxygen saturation (rSO2 ) measurements were started minutes before ECPR initiation until 3 h after. The primary outcome was regain of consciousness, defined as following commands, analyzed using binary logistic regression.RESULTS: The sample consisted of 26 ECPR patients (23% women, Agemean 46 years). We found no significant differences in rSO2 values at baseline (49.1% versus 49.3% for regain versus no regain of consciousness). Mean cerebral rSO2 values in the first 30 min after ECPR initiation were higher in patients who regained consciousness (38%) than in patients who did not regain consciousness (62%, odds ratio 1.23, 95% confidence interval 1.01-1.50).CONCLUSION: Higher mean cerebral rSO2 values in the first 30 min after initiation of ECPR were found in patients who regained consciousness.

KW - Adult

KW - Brain Ischemia/etiology

KW - Cardiopulmonary Resuscitation/adverse effects

KW - Consciousness

KW - Female

KW - Heart Arrest/complications

KW - Humans

KW - Male

KW - Middle Aged

KW - Out-of-Hospital Cardiac Arrest/therapy

KW - Oxygen Saturation

KW - Retrospective Studies

U2 - 10.1111/aor.14548

DO - 10.1111/aor.14548

M3 - Article

C2 - 37042484

SN - 0160-564X

VL - 47

SP - 1479

EP - 1489

JO - Artificial Organs

JF - Artificial Organs

IS - 9

ER -

Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness

Abstract

Keywords

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