High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease

Alexandra A J de Rotte; Amy Groenewegen; DR Rutgers; TD Witkamp; Pierre M J Zelissen; F J Anton Meijer; Erik J van Lindert; Ad Hermus; Peter R Luijten; J Hendrikse

doi:10.1007/s00330-015-3809-x

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease

Alexandra A J de Rotte, Amy Groenewegen, DR Rutgers, TD Witkamp, Pierre M J Zelissen, F J Anton Meijer, Erik J van Lindert, Ad Hermus, Peter R Luijten, J Hendrikse

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.

METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.

RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.

CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.

KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	European Radiology
Volume	26
Issue number	1
Early online date	20 May 2015
DOIs	https://doi.org/10.1007/s00330-015-3809-x
Publication status	Published - 2016

Access to Document

10.1007/s00330-015-3809-x

Cite this

@article{f4f52f92f486498280907b5784a11be4,

title = "High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease",

abstract = "OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T.",

author = "{de Rotte}, {Alexandra A J} and Amy Groenewegen and DR Rutgers and TD Witkamp and Zelissen, {Pierre M J} and Meijer, {F J Anton} and {van Lindert}, {Erik J} and Ad Hermus and Luijten, {Peter R} and J Hendrikse",

year = "2016",

doi = "10.1007/s00330-015-3809-x",

language = "English",

volume = "26",

pages = "271--277",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer-Verlag",

number = "1",

}

TY - JOUR

T1 - High resolution pituitary gland MRI at 7.0 tesla

T2 - a clinical evaluation in Cushing's disease

AU - de Rotte, Alexandra A J

AU - Groenewegen, Amy

AU - Rutgers, DR

AU - Witkamp, TD

AU - Zelissen, Pierre M J

AU - Meijer, F J Anton

AU - van Lindert, Erik J

AU - Hermus, Ad

AU - Luijten, Peter R

AU - Hendrikse, J

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T.

AB - OBJECTIVE: To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.METHODS: In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.RESULTS: The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.CONCLUSION: The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.KEY POINTS: • Interobserver agreement for lesion detection on 1.5 T MRI was good; • Interobserver agreement for lesion detection on 7.0 T MRI was good; • 7.0 T enabled confirmation of unclear lesions at 1.5 T; • 7.0 T enabled visualization of lesions not visible at 1.5 T.

U2 - 10.1007/s00330-015-3809-x

DO - 10.1007/s00330-015-3809-x

M3 - Article

C2 - 25991481

SN - 0938-7994

VL - 26

SP - 271

EP - 277

JO - European Radiology

JF - European Radiology

IS - 1

ER -

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease

Abstract

Access to Document

Fingerprint

Cite this