High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Zonne L.M. Hofman; Nikki Van West; C. Erik Hack; André C. Knulst; Coen Maas; Heike Röckmann

doi:10.1186/s13601-019-0274-7

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Zonne L.M. Hofman
, Nikki Van West
, C. Erik Hack
, André C. Knulst
, Coen Maas
, Heike Röckmann^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

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Abstract

Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.

Original language	English
Article number	35
Number of pages	5
Journal	Clinical and Translational Allergy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13601-019-0274-7
Publication status	Published - 12 Jul 2019

Keywords

Angioedema
Antihistamines
Idiopathic angioedema
Omalizumab

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title = "High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema",

abstract = "Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36\%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.",

keywords = "Angioedema, Antihistamines, Idiopathic angioedema, Omalizumab",

author = "Hofman, \{Zonne L.M.\} and \{Van West\}, Nikki and Hack, \{C. Erik\} and Knulst, \{Andr{\'e} C.\} and Coen Maas and Heike R{\"o}ckmann",

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T1 - High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

AU - Hofman, Zonne L.M.

AU - Van West, Nikki

AU - Hack, C. Erik

AU - Knulst, André C.

AU - Maas, Coen

AU - Röckmann, Heike

PY - 2019/7/12

Y1 - 2019/7/12

N2 - Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.

AB - Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.

KW - Angioedema

KW - Antihistamines

KW - Idiopathic angioedema

KW - Omalizumab

UR - https://www.scopus.com/pages/publications/85069491799

U2 - 10.1186/s13601-019-0274-7

DO - 10.1186/s13601-019-0274-7

M3 - Letter

C2 - 31338156

AN - SCOPUS:85069491799

SN - 2045-7022

VL - 9

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

IS - 1

M1 - 35

ER -

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

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Keywords

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