High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform

René Van Es; Maurits K. Konings; Bastiaan C. Du Pré; Kars Neven; Harry Van Wessel; Vincent J.H.M. Van Driel; Albert H. Westra; Pieter A.F. Doevendans; Fred H.M. Wittkampf

doi:10.1186/s12938-019-0693-7

High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform

René Van Es, Maurits K. Konings^*, Bastiaan C. Du Pré, Kars Neven, Harry Van Wessel, Vincent J.H.M. Van Driel, Albert H. Westra, Pieter A.F. Doevendans, Fred H.M. Wittkampf

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

Background: Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis.
Methods: In the present study, we introduce a novel asymmetric, high-frequency
(aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy.
Results: The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003).
Conclusion: We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method.

Original language	English
Article number	75
Pages (from-to)	75
Number of pages	13
Journal	BioMedical Engineering Online
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12938-019-0693-7
Publication status	Published - 20 Jun 2019

Keywords

Ablation Techniques/methods
Animals
Arrhythmias, Cardiac/physiopathology
Electric Conductivity
Electroporation/methods
Myocardial Contraction
Swine

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10.1186/s12938-019-0693-7

High-frequency irreversible electroporation for cardiac ablation...... van Es R _ Konings MK et al -- 12938_2019_Article_693Final published version, 1.27 MB

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@article{b99dedd8ce854b02809b02e545c201cd,

title = "High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform",

abstract = "Background: Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis.Methods: In the present study, we introduce a novel asymmetric, high-frequency(aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy.Results: The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003).Conclusion: We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method.",

keywords = "Ablation Techniques/methods, Animals, Arrhythmias, Cardiac/physiopathology, Electric Conductivity, Electroporation/methods, Myocardial Contraction, Swine",

author = "{Van Es}, Ren{\'e} and Konings, {Maurits K.} and {Du Pr{\'e}}, {Bastiaan C.} and Kars Neven and {Van Wessel}, Harry and {Van Driel}, {Vincent J.H.M.} and Westra, {Albert H.} and Doevendans, {Pieter A.F.} and Wittkampf, {Fred H.M.}",

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year = "2019",

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doi = "10.1186/s12938-019-0693-7",

language = "English",

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T1 - High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform

AU - Van Es, René

AU - Konings, Maurits K.

AU - Du Pré, Bastiaan C.

AU - Neven, Kars

AU - Van Wessel, Harry

AU - Van Driel, Vincent J.H.M.

AU - Westra, Albert H.

AU - Doevendans, Pieter A.F.

AU - Wittkampf, Fred H.M.

PY - 2019/6/20

Y1 - 2019/6/20

N2 - Background: Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis.Methods: In the present study, we introduce a novel asymmetric, high-frequency(aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy.Results: The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003).Conclusion: We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method.

AB - Background: Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis.Methods: In the present study, we introduce a novel asymmetric, high-frequency(aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy.Results: The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003).Conclusion: We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method.

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KW - Animals

KW - Arrhythmias, Cardiac/physiopathology

KW - Electric Conductivity

KW - Electroporation/methods

KW - Myocardial Contraction

KW - Swine

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ER -

High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform

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