High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities

M van Oosterhout; R J Verburg; E W N Levarht; J D Moolenburgh; R M Barge; W E Fibbe; J M van Laar

doi:10.1136/ard.2004.034793

High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities

M van Oosterhout, R J Verburg, E W N Levarht, J D Moolenburgh, R M Barge, W E Fibbe, J M van Laar

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Immunoablative therapy combined with haematopoietic stem cell transplantation (SCT) is a possible treatment for patients with severe rheumatoid arthritis (RA).

CASE REPORT: A patient with rheumatoid factor positive, progressively erosive RA, refractive to treatment, was treated with high dose cyclophosphamide, followed by reinfusion of an unmanipulated peripheral blood graft derived from her identical twin sister. The clinical response was unsatisfactory, necessitating reinstitution of treatment with disease modifying antirheumatic drugs, which was associated with persistence of host serum autoantibodies and a cellular infiltrate in synovium, notably of plasma cells.

DISCUSSION: The effectiveness of syngeneic SCT may be critically dependent on the degree of immunoablation achieved or on the composition of the graft.

Original language	English
Pages (from-to)	1783-5
Number of pages	3
Journal	Annals of the Rheumatic Diseases
Volume	64
Issue number	12
DOIs	https://doi.org/10.1136/ard.2004.034793
Publication status	Published - Dec 2005
Externally published	Yes

Keywords

Adult
Antirheumatic Agents
Arthritis, Rheumatoid
Autoantibodies
Cyclophosphamide
Female
Hematopoietic Stem Cell Transplantation
Humans
Immunosuppressive Agents
Synovial Membrane
Treatment Failure
Case Reports
Journal Article

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van Oosterhout, M., Verburg, R. J., Levarht, E. W. N., Moolenburgh, J. D., Barge, R. M., Fibbe, W. E., & van Laar, J. M. (2005). High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities. Annals of the Rheumatic Diseases, 64(12), 1783-5. https://doi.org/10.1136/ard.2004.034793

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title = "High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities",

abstract = "BACKGROUND: Immunoablative therapy combined with haematopoietic stem cell transplantation (SCT) is a possible treatment for patients with severe rheumatoid arthritis (RA).CASE REPORT: A patient with rheumatoid factor positive, progressively erosive RA, refractive to treatment, was treated with high dose cyclophosphamide, followed by reinfusion of an unmanipulated peripheral blood graft derived from her identical twin sister. The clinical response was unsatisfactory, necessitating reinstitution of treatment with disease modifying antirheumatic drugs, which was associated with persistence of host serum autoantibodies and a cellular infiltrate in synovium, notably of plasma cells.DISCUSSION: The effectiveness of syngeneic SCT may be critically dependent on the degree of immunoablation achieved or on the composition of the graft.",

keywords = "Adult, Antirheumatic Agents, Arthritis, Rheumatoid, Autoantibodies, Cyclophosphamide, Female, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppressive Agents, Synovial Membrane, Treatment Failure, Case Reports, Journal Article",

author = "{van Oosterhout}, M and Verburg, {R J} and Levarht, {E W N} and Moolenburgh, {J D} and Barge, {R M} and Fibbe, {W E} and {van Laar}, {J M}",

year = "2005",

month = dec,

doi = "10.1136/ard.2004.034793",

language = "English",

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van Oosterhout, M, Verburg, RJ, Levarht, EWN, Moolenburgh, JD, Barge, RM, Fibbe, WE & van Laar, JM 2005, 'High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities', Annals of the Rheumatic Diseases, vol. 64, no. 12, pp. 1783-5. https://doi.org/10.1136/ard.2004.034793

High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities. / van Oosterhout, M; Verburg, R J; Levarht, E W N et al.
In: Annals of the Rheumatic Diseases, Vol. 64, No. 12, 12.2005, p. 1783-5.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis

T2 - poor response associated with persistence of host autoantibodies and synovial abnormalities

AU - van Oosterhout, M

AU - Verburg, R J

AU - Levarht, E W N

AU - Moolenburgh, J D

AU - Barge, R M

AU - Fibbe, W E

AU - van Laar, J M

PY - 2005/12

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N2 - BACKGROUND: Immunoablative therapy combined with haematopoietic stem cell transplantation (SCT) is a possible treatment for patients with severe rheumatoid arthritis (RA).CASE REPORT: A patient with rheumatoid factor positive, progressively erosive RA, refractive to treatment, was treated with high dose cyclophosphamide, followed by reinfusion of an unmanipulated peripheral blood graft derived from her identical twin sister. The clinical response was unsatisfactory, necessitating reinstitution of treatment with disease modifying antirheumatic drugs, which was associated with persistence of host serum autoantibodies and a cellular infiltrate in synovium, notably of plasma cells.DISCUSSION: The effectiveness of syngeneic SCT may be critically dependent on the degree of immunoablation achieved or on the composition of the graft.

AB - BACKGROUND: Immunoablative therapy combined with haematopoietic stem cell transplantation (SCT) is a possible treatment for patients with severe rheumatoid arthritis (RA).CASE REPORT: A patient with rheumatoid factor positive, progressively erosive RA, refractive to treatment, was treated with high dose cyclophosphamide, followed by reinfusion of an unmanipulated peripheral blood graft derived from her identical twin sister. The clinical response was unsatisfactory, necessitating reinstitution of treatment with disease modifying antirheumatic drugs, which was associated with persistence of host serum autoantibodies and a cellular infiltrate in synovium, notably of plasma cells.DISCUSSION: The effectiveness of syngeneic SCT may be critically dependent on the degree of immunoablation achieved or on the composition of the graft.

KW - Adult

KW - Antirheumatic Agents

KW - Arthritis, Rheumatoid

KW - Autoantibodies

KW - Cyclophosphamide

KW - Female

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Immunosuppressive Agents

KW - Synovial Membrane

KW - Treatment Failure

KW - Case Reports

KW - Journal Article

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DO - 10.1136/ard.2004.034793

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SN - 0003-4967

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SP - 1783

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JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

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ER -

van Oosterhout M, Verburg RJ, Levarht EWN, Moolenburgh JD, Barge RM, Fibbe WE et al. High dose chemotherapy and syngeneic stem cell transplantation in a patient with refractory rheumatoid arthritis: poor response associated with persistence of host autoantibodies and synovial abnormalities. Annals of the Rheumatic Diseases. 2005 Dec;64(12):1783-5. doi: 10.1136/ard.2004.034793