High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

Ira M Mostovaya; Muriel P C Grooteman; Carlo Basile; Andrew Davenport; Camiel L M de Roij van Zuijdewijn; Christoph Wanner; Menso J Nubé; Peter Blankestijn

doi:10.1093/ckj/sfv040

High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

Ira M Mostovaya, Muriel P C Grooteman, Carlo Basile, Andrew Davenport, Camiel L M de Roij van Zuijdewijn, Christoph Wanner, Menso J Nubé, Peter Blankestijn

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the 'dose' of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.

Original language	English
Pages (from-to)	368-73
Number of pages	6
Journal	Clinical Kidney Journal
Volume	8
Issue number	4
DOIs	https://doi.org/10.1093/ckj/sfv040
Publication status	Published - Aug 2015

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title = "High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs",

abstract = "Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the 'dose' of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.",

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AU - Mostovaya, Ira M

AU - Grooteman, Muriel P C

AU - Basile, Carlo

AU - Davenport, Andrew

AU - de Roij van Zuijdewijn, Camiel L M

AU - Wanner, Christoph

AU - Nubé, Menso J

AU - Blankestijn, Peter

PY - 2015/8

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AB - Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the 'dose' of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.

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JO - Clinical Kidney Journal

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High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

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