HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas

Justin E Swartz; Inge Wegner; Rob Noorlag; Pauline M W van Kempen; Robert J J van Es; Remco de Bree; Stefan M W Willems

doi:10.1002/hed.26530

HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas

Justin E Swartz
, Inge Wegner
, Rob Noorlag
, Pauline M W van Kempen
, Robert J J van Es
, Remco de Bree
, Stefan M W Willems

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.

DESIGN/METHOD: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed.

RESULTS: HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC.

CONCLUSIONS: High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.

Original language	English
Pages (from-to)	745-756
Number of pages	12
Journal	Head & neck
Volume	43
Issue number	3
Early online date	5 Nov 2020
DOIs	https://doi.org/10.1002/hed.26530
Publication status	Published - Mar 2021

Keywords

head and neck neoplasms
hypoxia
oropharyngeal neoplasms
survival
tumor microenvironment

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10.1002/hed.26530

hed.26530Final published version, 2.01 MBLicence: Taverne

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title = "HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas",

abstract = "BACKGROUND: Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.DESIGN/METHOD: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed.RESULTS: HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC.CONCLUSIONS: High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.",

keywords = "head and neck neoplasms, hypoxia, oropharyngeal neoplasms, survival, tumor microenvironment",

author = "Swartz, \{Justin E\} and Inge Wegner and Rob Noorlag and \{van Kempen\}, \{Pauline M W\} and \{van Es\}, \{Robert J J\} and \{de Bree\}, Remco and Willems, \{Stefan M W\}",

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year = "2021",

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doi = "10.1002/hed.26530",

language = "English",

volume = "43",

pages = "745--756",

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T1 - HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas

AU - Swartz, Justin E

AU - Wegner, Inge

AU - Noorlag, Rob

AU - van Kempen, Pauline M W

AU - van Es, Robert J J

AU - de Bree, Remco

AU - Willems, Stefan M W

PY - 2021/3

Y1 - 2021/3

N2 - BACKGROUND: Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.DESIGN/METHOD: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed.RESULTS: HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC.CONCLUSIONS: High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.

AB - BACKGROUND: Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite.DESIGN/METHOD: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed.RESULTS: HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC.CONCLUSIONS: High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC.

KW - head and neck neoplasms

KW - hypoxia

KW - oropharyngeal neoplasms

KW - survival

KW - tumor microenvironment

UR - https://www.scopus.com/pages/publications/85096810846

U2 - 10.1002/hed.26530

DO - 10.1002/hed.26530

M3 - Article

C2 - 33155375

SN - 1043-3074

VL - 43

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EP - 756

JO - Head & neck

JF - Head & neck

IS - 3

ER -

HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas

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