Het natuurlijke beloop van het niet-functionerende hypofyseadenoom

Translated title of the contribution: The natural course of non-functioning pituitary adenomas

B H R Wolffenbuttel, G van den Berg, Eelco W Hoving, M M van der Klauw

Research output: Contribution to journalArticleAcademicpeer-review


3 patients presented with non-functioning pituitary adenomas: a 50-year-old woman who had an adenoma that had not increased in size for 3 years; a 68-year-old man with an adenoma that was undiagnosed for 5 years and led to pituitary insufficiency and bitemporal hemianopsia; and a 64-year-old woman, who had refused therapy and follow-up after diagnosis of the adenoma 20 years earlier. She was admitted with a hydrocephalus, pituitary insufficiency, and severe visual loss. The clinical symptoms of pituitary adenomas are caused by the mass effects of the tumour and may vary considerably between patients. Transsphenoidal surgery is indicated in cases of suprasellar extension with compression or impending compressing of the optic chiasm. A 'wait-and-see' approach can be used for patients with smaller tumours and no visual field defects. The natural course of these adenomas is such that lifelong follow-up is necessary. Postoperative radiotherapy can be effective in reducing recurrence rates without negative effects on quality of life.

Translated title of the contributionThe natural course of non-functioning pituitary adenomas
Original languageDutch
Pages (from-to)2537-43
Number of pages7
JournalNederlands Tijdschrift voor Geneeskunde
Issue number47
Publication statusPublished - 22 Nov 2008


  • Adenoma/pathology
  • Aged
  • Blindness/etiology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Pituitary Neoplasms/pathology
  • Prognosis
  • Quality of Life
  • Treatment Outcome


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