Heritability of menopausal age in mothers and daughters

Kristel M. van Asselt; Helen S. Kok; Peter L. Pearson; Judith S. Dubas; Petra H. M. Peeters; Egbert R. te Velde; Paulus A. H. van Noord

doi:10.1016/j.fertnstert.2004.04.047

Heritability of menopausal age in mothers and daughters

Kristel M. van Asselt
, Helen S. Kok
, Peter L. Pearson
, Judith S. Dubas
, Petra H. M. Peeters^*
, Egbert R. te Velde
, Paulus A. H. van Noord

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

Original language	English
Pages (from-to)	1348-1351
Number of pages	4
Journal	Fertility and Sterility
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2004.04.047
Publication status	Published - 2004

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title = "Heritability of menopausal age in mothers and daughters",

abstract = "Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44\% (95\% confidence interval, 36\%, 50\%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine",

author = "\{van Asselt\}, \{Kristel M.\} and Kok, \{Helen S.\} and Pearson, \{Peter L.\} and Dubas, \{Judith S.\} and Peeters, \{Petra H. M.\} and \{te Velde\}, \{Egbert R.\} and \{van Noord\}, \{Paulus A. H.\}",

year = "2004",

doi = "10.1016/j.fertnstert.2004.04.047",

language = "English",

volume = "82",

pages = "1348--1351",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Heritability of menopausal age in mothers and daughters

AU - van Asselt, Kristel M.

AU - Kok, Helen S.

AU - Pearson, Peter L.

AU - Dubas, Judith S.

AU - Peeters, Petra H. M.

AU - te Velde, Egbert R.

AU - van Noord, Paulus A. H.

PY - 2004

Y1 - 2004

N2 - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

AB - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

U2 - 10.1016/j.fertnstert.2004.04.047

DO - 10.1016/j.fertnstert.2004.04.047

M3 - Article

SN - 0015-0282

VL - 82

SP - 1348

EP - 1351

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

Heritability of menopausal age in mothers and daughters

Abstract

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