TY - JOUR
T1 - Heritability of menopausal age in mothers and daughters
AU - van Asselt, Kristel M.
AU - Kok, Helen S.
AU - Pearson, Peter L.
AU - Dubas, Judith S.
AU - Peeters, Petra H. M.
AU - te Velde, Egbert R.
AU - van Noord, Paulus A. H.
PY - 2004
Y1 - 2004
N2 - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine
AB - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine
U2 - 10.1016/j.fertnstert.2004.04.047
DO - 10.1016/j.fertnstert.2004.04.047
M3 - Article
SN - 0015-0282
VL - 82
SP - 1348
EP - 1351
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -