Hereditary Colorectal Cancer: Genetics and Screening

Lodewijk A A Brosens; G. Johan A Offerhaus; Francis M. Giardiello

doi:10.1016/j.suc.2015.05.004

Hereditary Colorectal Cancer: Genetics and Screening

Lodewijk A A Brosens^*
, G. Johan A Offerhaus
, Francis M. Giardiello

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

Original language	English
Pages (from-to)	1067-1080
Number of pages	14
Journal	Surgical Oncology Clinics of North America
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.suc.2015.05.004
Publication status	Published - 1 Jan 2015

Keywords

Colorectal cancer
Familial adenomatous polyposis
Hereditary nonpolyposis colorectal cancer
Lynch syndrome
MUTYH-associated polyposis

Access to Document

10.1016/j.suc.2015.05.004

Cite this

@article{b514908d53cf45db97aedf62ba6f6a0c,

title = "Hereditary Colorectal Cancer: Genetics and Screening",

abstract = "Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30\% of patients with CRC report a family history of CRC. However, only 5\% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.",

keywords = "Colorectal cancer, Familial adenomatous polyposis, Hereditary nonpolyposis colorectal cancer, Lynch syndrome, MUTYH-associated polyposis",

author = "Brosens, \{Lodewijk A A\} and Offerhaus, \{G. Johan A\} and Giardiello, \{Francis M.\}",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.suc.2015.05.004",

language = "English",

volume = "95",

pages = "1067--1080",

journal = "Surgical Oncology Clinics of North America",

issn = "0039-6109",

publisher = "W.B. Saunders",

number = "5",

}

TY - JOUR

T1 - Hereditary Colorectal Cancer

T2 - Genetics and Screening

AU - Brosens, Lodewijk A A

AU - Offerhaus, G. Johan A

AU - Giardiello, Francis M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

AB - Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

KW - Colorectal cancer

KW - Familial adenomatous polyposis

KW - Hereditary nonpolyposis colorectal cancer

KW - Lynch syndrome

KW - MUTYH-associated polyposis

UR - https://www.scopus.com/pages/publications/84940614646

U2 - 10.1016/j.suc.2015.05.004

DO - 10.1016/j.suc.2015.05.004

M3 - Article

C2 - 26315524

AN - SCOPUS:84940614646

SN - 0039-6109

VL - 95

SP - 1067

EP - 1080

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

IS - 5

ER -

Hereditary Colorectal Cancer: Genetics and Screening

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this