TY - JOUR
T1 - Hepatitis C virus in hemophilia
T2 - Health-related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study
AU - Isfordink, Cas J
AU - Gouw, Samantha C
AU - van Balen, Erna C
AU - Hassan, Shermarke
AU - Beckers, Erik A M
AU - van der Bom, Johanna G
AU - Coppens, Michiel
AU - Eikenboom, Jeroen
AU - Fischer, Kathelijn
AU - Hooimeijer, Louise
AU - Leebeek, Frank W G
AU - Rosendaal, Frits R
AU - Schols, Saskia E M
AU - Smit, Cees
AU - van Vulpen, Lize F D
AU - Mauser-Bunschoten, Eveline P
N1 - Funding Information:
The Haemophilia in the Netherlands study was made possible by an unrestricted grant from the Dutch Ministry of Health, Welfare and Sport, and by the Stichting Haemophilia/Haemophilia foundation. No funding was received to prepare this manuscript.
Publisher Copyright:
© 2021 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH)
PY - 2021/12
Y1 - 2021/12
N2 - Introduction: Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health-related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL between HCV-cured and never chronically HCV-infected persons with hemophilia.Methods: All persons with hemophilia in the Netherlands were invited for a nationwide study conducted in 2018-2019. For the current analysis, participants born before 1992 with data on HRQoL and HCV status were included. HCV status was collected from medical records. HRQoL was measured by RAND-36 questionnaire, with a minimally important difference set at 4.0 points. Multivariable linear regression was used to adjust for age, hemophilia severity, HIV status, and self-reported joint impairment.Results: In total, 486 persons were eligible; 180 were HCV cured and 306 never chronically HCV infected. Compared with those never HCV infected, HCV-cured individuals were older (57 vs. 53 years), more often had severe hemophilia (67% vs. 21%), and reported more impaired joints (median 3 vs. 0). Compared with those never HCV infected, adjusted RAND-36 domain scores of HCV-cured individuals cured were lower on all RAND-36 domains except Pain, ranging from a difference of 4.5 (95% CI, -8.8 to -0.3) for Physical functioning to 11.3 (95% CI, -19.4 to -3.1) for Role limitations due to physical problems.Conclusion: Despite effective HCV treatment, HRQoL of HCV-cured persons with hemophilia is still lower than HRQoL of those never chronically HCV-infected on all RAND-36 domains. This implies that careful psychosocial follow-up and support are indicated.
AB - Introduction: Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health-related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL between HCV-cured and never chronically HCV-infected persons with hemophilia.Methods: All persons with hemophilia in the Netherlands were invited for a nationwide study conducted in 2018-2019. For the current analysis, participants born before 1992 with data on HRQoL and HCV status were included. HCV status was collected from medical records. HRQoL was measured by RAND-36 questionnaire, with a minimally important difference set at 4.0 points. Multivariable linear regression was used to adjust for age, hemophilia severity, HIV status, and self-reported joint impairment.Results: In total, 486 persons were eligible; 180 were HCV cured and 306 never chronically HCV infected. Compared with those never HCV infected, HCV-cured individuals were older (57 vs. 53 years), more often had severe hemophilia (67% vs. 21%), and reported more impaired joints (median 3 vs. 0). Compared with those never HCV infected, adjusted RAND-36 domain scores of HCV-cured individuals cured were lower on all RAND-36 domains except Pain, ranging from a difference of 4.5 (95% CI, -8.8 to -0.3) for Physical functioning to 11.3 (95% CI, -19.4 to -3.1) for Role limitations due to physical problems.Conclusion: Despite effective HCV treatment, HRQoL of HCV-cured persons with hemophilia is still lower than HRQoL of those never chronically HCV-infected on all RAND-36 domains. This implies that careful psychosocial follow-up and support are indicated.
KW - RAND-36
KW - direct-acting antivirals
KW - hemophilia A
KW - hemophilia B
KW - hepatitis C virus
KW - patient reported outcome measures
KW - viral hepatitis
UR - http://www.scopus.com/inward/record.url?scp=85121865786&partnerID=8YFLogxK
U2 - 10.1002/rth2.12616
DO - 10.1002/rth2.12616
M3 - Article
C2 - 34870068
SN - 2475-0379
VL - 5
SP - 1
EP - 11
JO - Research and practice in thrombosis and haemostasis
JF - Research and practice in thrombosis and haemostasis
IS - 8
M1 - e12616
ER -