Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting

M Rondy; L Wiessing; S J Hutchinson; C Matheï; F Mathis; V Mravcik; L Norden; M Rosińska; O Scutelniciuc; B Suligoi; F Vallejo; M VAN Veen; M Kretzschmar

doi:10.1017/S0950268812000921

Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting

M Rondy, L Wiessing, S J Hutchinson, C Matheï, F Mathis, V Mravcik, L Norden, M Rosińska, O Scutelniciuc, B Suligoi, F Vallejo, M VAN Veen, M Kretzschmar

Julius Center, dept. Epidemiology & Health Economics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.

Original language	English
Pages (from-to)	563-572
Number of pages	10
Journal	Epidemiology and Infection
Volume	141
Issue number	3
DOIs	https://doi.org/10.1017/S0950268812000921
Publication status	Published - Mar 2013

Keywords

Adult
Europe/epidemiology
Female
Hepatitis C/epidemiology
Humans
Male
Needle-Exchange Programs
Patient Selection
Prevalence
Research Design
Selection Bias
Seroepidemiologic Studies
Substance Abuse Treatment Centers
Substance Abuse, Intravenous/epidemiology

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Rondy, M., Wiessing, L., Hutchinson, S. J., Matheï, C., Mathis, F., Mravcik, V., Norden, L., Rosińska, M., Scutelniciuc, O., Suligoi, B., Vallejo, F., VAN Veen, M., & Kretzschmar, M. (2013). Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting. Epidemiology and Infection, 141(3), 563-572. https://doi.org/10.1017/S0950268812000921

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title = "Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting",

abstract = "Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.",

keywords = "Adult, Europe/epidemiology, Female, Hepatitis C/epidemiology, Humans, Male, Needle-Exchange Programs, Patient Selection, Prevalence, Research Design, Selection Bias, Seroepidemiologic Studies, Substance Abuse Treatment Centers, Substance Abuse, Intravenous/epidemiology",

author = "M Rondy and L Wiessing and Hutchinson, {S J} and C Mathe{\"i} and F Mathis and V Mravcik and L Norden and M Rosi{\'n}ska and O Scutelniciuc and B Suligoi and F Vallejo and {VAN Veen}, M and M Kretzschmar",

year = "2013",

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doi = "10.1017/S0950268812000921",

language = "English",

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Rondy, M, Wiessing, L, Hutchinson, SJ, Matheï, C, Mathis, F, Mravcik, V, Norden, L, Rosińska, M, Scutelniciuc, O, Suligoi, B, Vallejo, F, VAN Veen, M & Kretzschmar, M 2013, 'Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting', Epidemiology and Infection, vol. 141, no. 3, pp. 563-572. https://doi.org/10.1017/S0950268812000921

TY - JOUR

T1 - Hepatitis C prevalence in injecting drug users in Europe, 1990-2007

T2 - impact of study recruitment setting

AU - Rondy, M

AU - Wiessing, L

AU - Hutchinson, S J

AU - Matheï, C

AU - Mathis, F

AU - Mravcik, V

AU - Norden, L

AU - Rosińska, M

AU - Scutelniciuc, O

AU - Suligoi, B

AU - Vallejo, F

AU - VAN Veen, M

AU - Kretzschmar, M

PY - 2013/3

Y1 - 2013/3

N2 - Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.

AB - Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.

KW - Adult

KW - Europe/epidemiology

KW - Female

KW - Hepatitis C/epidemiology

KW - Humans

KW - Male

KW - Needle-Exchange Programs

KW - Patient Selection

KW - Prevalence

KW - Research Design

KW - Selection Bias

KW - Seroepidemiologic Studies

KW - Substance Abuse Treatment Centers

KW - Substance Abuse, Intravenous/epidemiology

U2 - 10.1017/S0950268812000921

DO - 10.1017/S0950268812000921

M3 - Article

C2 - 22595549

SN - 0950-2688

VL - 141

SP - 563

EP - 572

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 3

ER -

Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting

Abstract

Keywords

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