Hemophilic Arthropathy

Lize F.D. Van Vulpen; Floris P.J.G. Lafeber; Simon C. Mastbergen

doi:10.1016/B978-0-323-93540-1.00124-X

Hemophilic Arthropathy

Lize F.D. Van Vulpen, Floris P.J.G. Lafeber, Simon C. Mastbergen

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The most common rheumatologic complication in severe hemophilia is hemophilic arthropathy, which mainly affects the elbows, knees, and ankles. A combined cascade of degenerative and inflammatory processes initiated by recurrent joint bleeds leads to hemophilic arthropathy. Other musculoskeletal complications of hemophilia are muscle and soft tissue hemorrhage, chronic synovitis resulting from the inflammatory processes, pseudotumors, and osteoporosis. Treatment aims at prevention of recurrent hemarthrosis through prophylactic (non)factor replacement therapy. If conservative measures fail, orthopedic surgery, including total joint replacement, is indicated and can be performed safely with clotting factor replacement therapy.

Original language	English
Title of host publication	Firestein & Kelley's Textbook of Rheumatology, 2-Volume Set
Publisher	Elsevier
Pages	2146-2158.e5
Volume	2
Edition	12
ISBN (Electronic)	9780323935401
ISBN (Print)	9780323935906
DOIs	https://doi.org/10.1016/B978-0-323-93540-1.00124-X
Publication status	Published - 1 Jan 2024

Keywords

diagnostic approach
hemarthrosis
hemophilia
hemophilic arthropathy
pathogenesis
treatment

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10.1016/B978-0-323-93540-1.00124-X

Cite this

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title = "Hemophilic Arthropathy",

abstract = "The most common rheumatologic complication in severe hemophilia is hemophilic arthropathy, which mainly affects the elbows, knees, and ankles. A combined cascade of degenerative and inflammatory processes initiated by recurrent joint bleeds leads to hemophilic arthropathy. Other musculoskeletal complications of hemophilia are muscle and soft tissue hemorrhage, chronic synovitis resulting from the inflammatory processes, pseudotumors, and osteoporosis. Treatment aims at prevention of recurrent hemarthrosis through prophylactic (non)factor replacement therapy. If conservative measures fail, orthopedic surgery, including total joint replacement, is indicated and can be performed safely with clotting factor replacement therapy.",

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AU - Lafeber, Floris P.J.G.

AU - Mastbergen, Simon C.

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AB - The most common rheumatologic complication in severe hemophilia is hemophilic arthropathy, which mainly affects the elbows, knees, and ankles. A combined cascade of degenerative and inflammatory processes initiated by recurrent joint bleeds leads to hemophilic arthropathy. Other musculoskeletal complications of hemophilia are muscle and soft tissue hemorrhage, chronic synovitis resulting from the inflammatory processes, pseudotumors, and osteoporosis. Treatment aims at prevention of recurrent hemarthrosis through prophylactic (non)factor replacement therapy. If conservative measures fail, orthopedic surgery, including total joint replacement, is indicated and can be performed safely with clotting factor replacement therapy.

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KW - hemophilic arthropathy

KW - pathogenesis

KW - treatment

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Hemophilic Arthropathy

Abstract

Keywords

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