Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

Lex M van Loon; Johannes G van der Hoeven; Joris Lemson

doi:10.1016/j.jcrc.2018.12.003

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

Lex M van Loon
, Johannes G van der Hoeven
, Joris Lemson

Research output: Contribution to journal › Review article › peer-review

Abstract

The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

Original language	English
Pages (from-to)	138-143
Number of pages	6
Journal	Journal of Critical Care
Volume	50
DOIs	https://doi.org/10.1016/j.jcrc.2018.12.003
Publication status	Published - Apr 2019
Externally published	Yes

Keywords

Heart failure
Hemodynamics
Microcirculation, V-A coupling
Septic shock
β-blocker

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10.1016/j.jcrc.2018.12.003

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title = "Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature",

abstract = "The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.",

keywords = "Heart failure, Hemodynamics, Microcirculation, V-A coupling, Septic shock, β-blocker",

author = "\{van Loon\}, \{Lex M\} and \{van der Hoeven\}, \{Johannes G\} and Joris Lemson",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.jcrc.2018.12.003",

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AU - van der Hoeven, Johannes G

AU - Lemson, Joris

PY - 2019/4

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N2 - The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

AB - The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.

KW - Heart failure

KW - Hemodynamics

KW - Microcirculation, V-A coupling

KW - Septic shock

KW - β-blocker

UR - https://www.scopus.com/pages/publications/85057733571

U2 - 10.1016/j.jcrc.2018.12.003

DO - 10.1016/j.jcrc.2018.12.003

M3 - Review article

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SP - 138

EP - 143

JO - Journal of Critical Care

JF - Journal of Critical Care

ER -

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

Abstract

Keywords

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