TY - JOUR
T1 - Hemodynamic response to β-blockers in severe sepsis and septic shock
T2 - A review of current literature
AU - van Loon, Lex M
AU - van der Hoeven, Johannes G
AU - Lemson, Joris
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/4
Y1 - 2019/4
N2 - The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.
AB - The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients.
KW - Heart failure
KW - Hemodynamics
KW - Microcirculation, V-A coupling
KW - Septic shock
KW - β-blocker
UR - http://www.scopus.com/inward/record.url?scp=85057733571&partnerID=8YFLogxK
U2 - 10.1016/j.jcrc.2018.12.003
DO - 10.1016/j.jcrc.2018.12.003
M3 - Review article
C2 - 30540967
SN - 0883-9441
VL - 50
SP - 138
EP - 143
JO - Journal of Critical Care
JF - Journal of Critical Care
ER -