Hemodynamic assessment of the patent ductus arteriosus: Beyond ultrasound

M Kluckow, P Lemmers

Research output: Contribution to journalArticleAcademicpeer-review


Assessment and management of a patent ductus arteriosus (PDA) in premature infants remains problematic. The more immature the infant, the more likely a PDA is to be present, due to lower spontaneous PDA closure rates. Clinicians now recognize that not all PDAs require treatment and that selection of the group of infants with a more hemodynamically relevant PDA, often manifesting as an increasing systemic-to-pulmonary shunt, is increasingly important. Ultrasound is the mainstay of diagnosis and physiological assessment of the PDA; however, there are other methodologies used to assess hemodynamic importance of the PDA. These range from assessment of clinical signs through biomarkers and finally to physiological assessment of the end-organ effect of the PDA, using methods such as cerebral Doppler or near infra-red spectroscopy. Extended assessment of a PDA's physiological effect may lead to a more individualized approach to PDA treatment.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalSeminars in Fetal & Neonatal Medicine
Issue number4
Publication statusPublished - Aug 2018


  • Ductus Arteriosus, Patent/diagnostic imaging
  • Gestational Age
  • Hemodynamics/physiology
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Spectroscopy, Near-Infrared
  • Ultrasonography, Doppler
  • Patent ductus arteriosus
  • Near-infrared spectroscopy
  • Preterm
  • Neonate
  • Hemodynamics


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