TY - JOUR
T1 - Hematological Parameters Outperform Plasma Markers in Predicting Long-Term Mortality After Coronary Angiography
AU - Gijsberts, Crystel M.
AU - den Ruijter, Hester M.
AU - de Kleijn, Dominique P.V.
AU - Huisman, Albert
AU - ten Berg, Maarten
AU - de Groot, Mark
AU - van Wijk, Richard H.A.
AU - Asselbergs, Folkert W.
AU - Voskuil, Michiel
AU - Pasterkamp, Gerard
AU - van Solinge, Wouter W.
AU - Hoefer, Imo E.
N1 - Publisher Copyright:
© 2017, The Author(s) 2017.
PY - 2018
Y1 - 2018
N2 - High-sensitivity troponin I (hsTnI) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) are predictors of coronary artery disease. Recently, routine hematological parameters emerged as mortality predictors. We examined the predictive value of hematological parameters (from the Utrecht Patient Oriented Database) and hsTnI and NT-pro-BNP for mortality in a coronary angiography population (Utrecht Coronary Biobank n = 1913). Using Cox regression, receiver operating characteristics, integrated discrimination improvement (IDI), and continuous net reclassification improvement (cNRI) analysis, we compared the predictive properties of hematological parameters with hsTnI and NT-pro-BNP for mortality. During a median follow-up duration of 1.8 years, 77 deaths occurred. A panel of 7 hematological parameters (leukocyte count, reticulocyte mean corpuscular hemoglobin concentration, red blood cell [RBC] green (FL1) fluorescence, %neutrophils, %large [>120 fL] RBCs, %monocytes, and coefficient of variation of neutrophil complexity) was highly predictive. Added to clinical characteristics, hematological parameters (area under the curve [AUC]: 0.855, P <.001; IDI: 0.04, P =.02; cNRI: 0.41, P <.001) were better predictors than hsTnI (AUC: 0.818) or NT-pro-BNP (AUC: 0.834) alone or combined (AUC: 0.834). Hematological parameters may provide mortality risk information following coronary angiography and may be superior to hsTnI and/or NT-pro-BNP.
AB - High-sensitivity troponin I (hsTnI) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) are predictors of coronary artery disease. Recently, routine hematological parameters emerged as mortality predictors. We examined the predictive value of hematological parameters (from the Utrecht Patient Oriented Database) and hsTnI and NT-pro-BNP for mortality in a coronary angiography population (Utrecht Coronary Biobank n = 1913). Using Cox regression, receiver operating characteristics, integrated discrimination improvement (IDI), and continuous net reclassification improvement (cNRI) analysis, we compared the predictive properties of hematological parameters with hsTnI and NT-pro-BNP for mortality. During a median follow-up duration of 1.8 years, 77 deaths occurred. A panel of 7 hematological parameters (leukocyte count, reticulocyte mean corpuscular hemoglobin concentration, red blood cell [RBC] green (FL1) fluorescence, %neutrophils, %large [>120 fL] RBCs, %monocytes, and coefficient of variation of neutrophil complexity) was highly predictive. Added to clinical characteristics, hematological parameters (area under the curve [AUC]: 0.855, P <.001; IDI: 0.04, P =.02; cNRI: 0.41, P <.001) were better predictors than hsTnI (AUC: 0.818) or NT-pro-BNP (AUC: 0.834) alone or combined (AUC: 0.834). Hematological parameters may provide mortality risk information following coronary angiography and may be superior to hsTnI and/or NT-pro-BNP.
KW - biomarkers
KW - coronary artery disease
KW - mortality
UR - http://www.scopus.com/inward/record.url?scp=85043323514&partnerID=8YFLogxK
U2 - 10.1177/0003319717743679
DO - 10.1177/0003319717743679
M3 - Article
C2 - 29202601
SN - 0003-3197
VL - 69
SP - 600
EP - 608
JO - Angiology
JF - Angiology
IS - 7
ER -