Abstract
Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen-specific immunotherapy for autoimmune diseases. Heat shock proteins are bystander antigens that are effective in peptide-specific immunotherapy in both experimental and human autoimmune disease. The efficacy of preventive peptide immunotherapy is increased by enhancing peptide-specific immune responses with proinflammatory agents. Combining peptide-specific immunotherapy with general suppression of inflammation may improve its therapeutic effect.
| Translated title of the contribution | Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease. |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 20-29 |
| Number of pages | 10 |
| Journal | Clinical and Experimental Immunology |
| Volume | 171 |
| Issue number | 1 |
| Publication status | Published - 2013 |