TY - JOUR
T1 - Heart failure with preserved, mid-range, and reduced ejection fraction across health care settings
T2 - an observational study
AU - de Boer, Annemarijn R.
AU - Vaartjes, Ilonca
AU - Gohar, Aisha
AU - Valk, Mark J.M.
AU - Brugts, Jasper J.
AU - Boonman-de Winter, Leandra J.M.
AU - van Riet, Evelien E.
AU - van Mourik, Yvonne
AU - Brunner-La Rocca, Hans Peter
AU - Linssen, Gerard C.M.
AU - Hoes, Arno W.
AU - Bots, Michiel L.
AU - den Ruijter, Hester M.
AU - Rutten, Frans H.
N1 - Funding Information:
This work was supported by several grants from the Dutch Heart Foundation: Cardiovascular Disease in the Netherlands (Hartstichting) (grant Facts and Figures to A.R.B. and I.V. and grant numbers CVON 2014‐11 RECONNECT to H.R. and F.R., CVON 2013T084 Queen of Hearts to H.R. and F.R.) and ZonMw (grant number 849100003, Reviews en Kennissynthese Gender en Gezondheid to H.R. and F.R.).
Funding Information:
This work was supported by several grants from the Dutch Heart Foundation: Cardiovascular Disease in the Netherlands (Hartstichting) (grant Facts and Figures to A.R.B. and I.V. and grant numbers CVON 2014-11 RECONNECT to H.R. and F.R., CVON 2013T084 Queen of Hearts to H.R. and F.R.) and ZonMw (grant number 849100003, Reviews en Kennissynthese Gender en Gezondheid to H.R. and F.R.). Servier, the Netherlands, funded the inclusion of data and software programme for CHECK-HF. The steering committee of CHECK-HF (J.B., G.L., A.H., and H.B.R.L.R.) received no funding for this project. This combined analysis was initiated by the authors and was designed, conducted, interpreted, and reported independently of the sponsor. The current study had no other funding source or any with a participating role in outcome assessment, or writing of the manuscript.
Publisher Copyright:
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
PY - 2021/12/9
Y1 - 2021/12/9
N2 - Aims: This study aimed to assess the sex-specific distribution of heart failure (HF) with preserved, mid-range, and reduced ejection fraction across three health care settings. Methods and results: In this descriptive observational study, we retrieved the distribution of HF types [with reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmrEF), and preserved ejection fraction (HFpEF)] for men and women between 65 and 79 years of age in three health care settings from a single country: (i) patients with screening-detected HF in the high-risk community (i.e. those with shortness of breath, frailty, diabetes mellitus, and chronic obstructive pulmonary disease) from four screening studies, (ii) patients with confirmed HF from primary care derived from a single observational study, and (iii) patients with confirmed HF from outpatient cardiology clinics participating in a registry. Among 1407 patients from the high-risk community, 288 had screen-detected HF (15% HFrEF, 12% HFmrEF, 74% HFpEF), and 51% of the screen-detected HF patients were women. In both women (82%) and men (65%), HFpEF was the most prevalent HF type. In the routine general practice population (30 practices, 70 000 individuals), among the 160 confirmed HF cases, 35% had HFrEF, 23% HFmrEF, and 43% HFpEF, and in total, 43% were women. In women, HFpEF was the most prevalent HF type (52%), while in men, this was HFrEF (41%). In outpatient cardiology clinics (n = 34), of the 4742 HF patients (66% HFrEF, 15% HFmrEF, 20% HFpEF), 36% were women. In both women (56%) and men (71%), HFrEF was the most prevalent HF type. Conclusions: Both HF types and sex distribution vary considerably in HF patients of 65–79 years of age among health care settings. From the high-risk community through to general practice to the cardiology outpatient setting, there is a shift in HF type from HFpEF to HFrEF and a decrease in the proportion of HF patients that are women.
AB - Aims: This study aimed to assess the sex-specific distribution of heart failure (HF) with preserved, mid-range, and reduced ejection fraction across three health care settings. Methods and results: In this descriptive observational study, we retrieved the distribution of HF types [with reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmrEF), and preserved ejection fraction (HFpEF)] for men and women between 65 and 79 years of age in three health care settings from a single country: (i) patients with screening-detected HF in the high-risk community (i.e. those with shortness of breath, frailty, diabetes mellitus, and chronic obstructive pulmonary disease) from four screening studies, (ii) patients with confirmed HF from primary care derived from a single observational study, and (iii) patients with confirmed HF from outpatient cardiology clinics participating in a registry. Among 1407 patients from the high-risk community, 288 had screen-detected HF (15% HFrEF, 12% HFmrEF, 74% HFpEF), and 51% of the screen-detected HF patients were women. In both women (82%) and men (65%), HFpEF was the most prevalent HF type. In the routine general practice population (30 practices, 70 000 individuals), among the 160 confirmed HF cases, 35% had HFrEF, 23% HFmrEF, and 43% HFpEF, and in total, 43% were women. In women, HFpEF was the most prevalent HF type (52%), while in men, this was HFrEF (41%). In outpatient cardiology clinics (n = 34), of the 4742 HF patients (66% HFrEF, 15% HFmrEF, 20% HFpEF), 36% were women. In both women (56%) and men (71%), HFrEF was the most prevalent HF type. Conclusions: Both HF types and sex distribution vary considerably in HF patients of 65–79 years of age among health care settings. From the high-risk community through to general practice to the cardiology outpatient setting, there is a shift in HF type from HFpEF to HFrEF and a decrease in the proportion of HF patients that are women.
KW - Heart failure
KW - HFmrEF
KW - HFrEF
KW - Screening
KW - Sex differences
UR - https://www.scopus.com/pages/publications/85120897316
U2 - 10.1002/ehf2.13742
DO - 10.1002/ehf2.13742
M3 - Article
C2 - 34889076
AN - SCOPUS:85120897316
SN - 2055-5822
VL - 9
SP - 363
EP - 372
JO - ESC heart failure
JF - ESC heart failure
IS - 1
ER -