Healthy volunteer studies in toxicology

J. Meulenbelt; Tj T. Mensinga; J. M. Kortboyer; G. J A Speijers; I. De Vries

doi:10.1016/S0378-4274(98)00276-8

Healthy volunteer studies in toxicology

J. Meulenbelt^*, Tj T. Mensinga, J. M. Kortboyer, G. J A Speijers, I. De Vries

^*Corresponding author for this work

Clinical Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

In the future there will be an increasing need for quantitative human risk assessment in order to develop soundly-based risk level regulations. Human volunteer studies can contribute to gain essential data needed for this risk assessment. Volunteer studies are especially relevant to study the biokinetics and metabolism of a compound. Comparison of these data with those of laboratory animals can increase the accuracy in extrapolation study results from animals to man. Furthermore, the results of volunteer studies can be used to fill in the gaps of knowledge which cannot be solved with in vitro or animal studies in order to develop adequate physiologically-based biokinetic or biodynamic models for human risk assessment. Copyright (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Toxicology Letters
Volume	102-103
DOIs	https://doi.org/10.1016/S0378-4274(98)00276-8
Publication status	Published - 28 Dec 1998

Keywords

Biodynamic models
Biokinetic models
Human volunteer studies
Risk assessment

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10.1016/S0378-4274(98)00276-8

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title = "Healthy volunteer studies in toxicology",

abstract = "In the future there will be an increasing need for quantitative human risk assessment in order to develop soundly-based risk level regulations. Human volunteer studies can contribute to gain essential data needed for this risk assessment. Volunteer studies are especially relevant to study the biokinetics and metabolism of a compound. Comparison of these data with those of laboratory animals can increase the accuracy in extrapolation study results from animals to man. Furthermore, the results of volunteer studies can be used to fill in the gaps of knowledge which cannot be solved with in vitro or animal studies in order to develop adequate physiologically-based biokinetic or biodynamic models for human risk assessment. Copyright (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.",

keywords = "Biodynamic models, Biokinetic models, Human volunteer studies, Risk assessment",

author = "J. Meulenbelt and Mensinga, {Tj T.} and Kortboyer, {J. M.} and Speijers, {G. J A} and {De Vries}, I.",

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AU - Mensinga, Tj T.

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AU - Speijers, G. J A

AU - De Vries, I.

PY - 1998/12/28

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AB - In the future there will be an increasing need for quantitative human risk assessment in order to develop soundly-based risk level regulations. Human volunteer studies can contribute to gain essential data needed for this risk assessment. Volunteer studies are especially relevant to study the biokinetics and metabolism of a compound. Comparison of these data with those of laboratory animals can increase the accuracy in extrapolation study results from animals to man. Furthermore, the results of volunteer studies can be used to fill in the gaps of knowledge which cannot be solved with in vitro or animal studies in order to develop adequate physiologically-based biokinetic or biodynamic models for human risk assessment. Copyright (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Healthy volunteer studies in toxicology

Abstract

Keywords

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