Healthy aging and disease: role for telomere biology?

Haidong Zhu; Matthew Belcher; Pim van der Harst

doi:10.1042/CS20100385

Healthy aging and disease: role for telomere biology?

Haidong Zhu, Matthew Belcher, Pim van der Harst

Research output: Contribution to journal › Review article › peer-review

Abstract

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

Original language	English
Pages (from-to)	427-40
Number of pages	14
Journal	Clinical Science
Volume	120
Issue number	10
DOIs	https://doi.org/10.1042/CS20100385
Publication status	Published - May 2011
Externally published	Yes

Keywords

Aging/genetics
Cardiovascular Diseases/genetics
Chronic Disease
Diabetes Mellitus/genetics
Humans
Stem Cells/physiology
Telomerase/physiology
Telomere/physiology

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10.1042/CS20100385

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title = "Healthy aging and disease: role for telomere biology?",

abstract = "Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.",

keywords = "Aging/genetics, Cardiovascular Diseases/genetics, Chronic Disease, Diabetes Mellitus/genetics, Humans, Stem Cells/physiology, Telomerase/physiology, Telomere/physiology",

author = "Haidong Zhu and Matthew Belcher and {van der Harst}, Pim",

year = "2011",

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doi = "10.1042/CS20100385",

language = "English",

volume = "120",

pages = "427--40",

journal = "Clinical Science",

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T2 - role for telomere biology?

AU - Zhu, Haidong

AU - Belcher, Matthew

AU - van der Harst, Pim

PY - 2011/5

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N2 - Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

AB - Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

KW - Aging/genetics

KW - Cardiovascular Diseases/genetics

KW - Chronic Disease

KW - Diabetes Mellitus/genetics

KW - Humans

KW - Stem Cells/physiology

KW - Telomerase/physiology

KW - Telomere/physiology

U2 - 10.1042/CS20100385

DO - 10.1042/CS20100385

M3 - Review article

C2 - 21271986

SN - 0143-5221

VL - 120

SP - 427

EP - 440

JO - Clinical Science

JF - Clinical Science

IS - 10

ER -

Healthy aging and disease: role for telomere biology?

Abstract

Keywords

Access to Document

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Cite this