Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Andrés Coca-Pelaz; Robert P Takes; Kate Hutcheson; Nabil F Saba; Missak Haigentz; Carol R Bradford; Remco de Bree; Primož Strojan; Valerie J Lund; William M Mendenhall; Iain J Nixon; Miquel Quer; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s12325-018-0663-7

Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Andrés Coca-Pelaz, Robert P Takes, Kate Hutcheson, Nabil F Saba, Missak Haigentz, Carol R Bradford, Remco de Bree, Primož Strojan, Valerie J Lund, William M Mendenhall, Iain J Nixon, Miquel Quer, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journal › Review article › peer-review

Abstract

Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

Original language	English
Pages (from-to)	153-160
Number of pages	8
Journal	Advances in Therapy
Volume	35
Issue number	2
Early online date	2 Feb 2018
DOIs	https://doi.org/10.1007/s12325-018-0663-7
Publication status	Published - Feb 2018

Keywords

Journal Article
Review
Prognosis
Treatment
Head and neck cancer
Oncology
Survival
Waiting time
Squamous Cell Carcinoma of Head and Neck/diagnosis
Humans
Middle Aged
Patient Care Team
Male
Treatment Outcome
Time-to-Treatment/statistics & numerical data
Female
Practice Guidelines as Topic

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10.1007/s12325-018-0663-7

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title = "Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome",

abstract = "Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).",

keywords = "Journal Article, Review, Prognosis, Treatment, Head and neck cancer, Oncology, Survival, Waiting time, Squamous Cell Carcinoma of Head and Neck/diagnosis, Humans, Middle Aged, Patient Care Team, Male, Treatment Outcome, Time-to-Treatment/statistics & numerical data, Female, Practice Guidelines as Topic",

author = "Andr{\'e}s Coca-Pelaz and Takes, {Robert P} and Kate Hutcheson and Saba, {Nabil F} and Missak Haigentz and Bradford, {Carol R} and {de Bree}, Remco and Primo{\v z} Strojan and Lund, {Valerie J} and Mendenhall, {William M} and Nixon, {Iain J} and Miquel Quer and Alessandra Rinaldo and Alfio Ferlito",

year = "2018",

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doi = "10.1007/s12325-018-0663-7",

language = "English",

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journal = "Advances in Therapy",

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AU - Coca-Pelaz, Andrés

AU - Takes, Robert P

AU - Hutcheson, Kate

AU - Saba, Nabil F

AU - Haigentz, Missak

AU - Bradford, Carol R

AU - de Bree, Remco

AU - Strojan, Primož

AU - Lund, Valerie J

AU - Mendenhall, William M

AU - Nixon, Iain J

AU - Quer, Miquel

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018/2

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N2 - Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

AB - Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

KW - Journal Article

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KW - Prognosis

KW - Treatment

KW - Head and neck cancer

KW - Oncology

KW - Survival

KW - Waiting time

KW - Squamous Cell Carcinoma of Head and Neck/diagnosis

KW - Humans

KW - Middle Aged

KW - Patient Care Team

KW - Male

KW - Treatment Outcome

KW - Time-to-Treatment/statistics & numerical data

KW - Female

KW - Practice Guidelines as Topic

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VL - 35

SP - 153

EP - 160

JO - Advances in Therapy

JF - Advances in Therapy

IS - 2

ER -

Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

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Keywords

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