TY - JOUR
T1 - Hazelnut allergy across Europe dissected molecularly
T2 - A EuroPrevall outpatient clinic survey
AU - Datema, Mareen R.
AU - Zuidmeer-Jongejan, Laurian
AU - Asero, Riccardo
AU - Barreales, Laura
AU - Belohlavkova, Simona
AU - de Blay, Frederic
AU - Bures, Peter
AU - Clausen, Michael
AU - Dubakiene, Ruta
AU - Gislason, David
AU - Jedrzejczak-Czechowicz, Monika
AU - Kowalski, Marek L.
AU - Knulst, Andre C.
AU - Kralimarkova, Tanya
AU - Le, Thuy-My
AU - Lovegrove, Alison
AU - Marsh, Justin
AU - Papadopoulos, Nikolaos G.
AU - Popov, Todor
AU - del Prado, Nayade
AU - Purohit, Ashok
AU - Reese, Gerald
AU - Reig, Isabel
AU - Seneviratne, Suranjith L.
AU - Sinaniotis, Athanasios
AU - Versteeg, Serge A.
AU - Vieths, Stefan
AU - Zwinderman, Aeilko H.
AU - Mills, Clare
AU - Lidholm, Jonas
AU - Hoffmann-Sommergruber, Karin
AU - Fernandez-Rivas, Montserrat
AU - Ballmer-Weber, Barbara
AU - van Ree, Ronald
PY - 2015/8
Y1 - 2015/8
N2 - Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.Objective: Establishing a molecular map of hazelnut allergy across Europe.Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.
AB - Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.Objective: Establishing a molecular map of hazelnut allergy across Europe.Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.
KW - EuroPrevall
KW - hazelnut allergy
KW - component-resolved diagnosis
KW - outpatient clinic
KW - LIPID-TRANSFER PROTEIN
KW - CONTROLLED FOOD CHALLENGE
KW - POSITIVE DOUBLE-BLIND
KW - PLANT-DERIVED FOODS
KW - CROSS-REACTIVITY
KW - IGE-BINDING
KW - CORYLUS-AVELLANA
KW - MAJOR ALLERGENS
KW - PEANUT OLEOSIN
KW - IDENTIFICATION
U2 - 10.1016/j.jaci.2014.12.1949
DO - 10.1016/j.jaci.2014.12.1949
M3 - Article
SN - 0091-6749
VL - 136
SP - 382
EP - 391
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -