Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Mareen R. Datema; Laurian Zuidmeer-Jongejan; Riccardo Asero; Laura Barreales; Simona Belohlavkova; Frederic de Blay; Peter Bures; Michael Clausen; Ruta Dubakiene; David Gislason; Monika Jedrzejczak-Czechowicz; Marek L. Kowalski; Andre C. Knulst; Tanya Kralimarkova; Thuy-My Le; Alison Lovegrove; Justin Marsh; Nikolaos G. Papadopoulos; Todor Popov; Nayade del Prado; Ashok Purohit; Gerald Reese; Isabel Reig; Suranjith L. Seneviratne; Athanasios Sinaniotis; Serge A. Versteeg; Stefan Vieths; Aeilko H. Zwinderman; Clare Mills; Jonas Lidholm; Karin Hoffmann-Sommergruber; Montserrat Fernandez-Rivas; Barbara Ballmer-Weber; Ronald van Ree

doi:10.1016/j.jaci.2014.12.1949

Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Mareen R. Datema, Laurian Zuidmeer-Jongejan, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frederic de Blay, Peter Bures, Michael Clausen, Ruta Dubakiene, David Gislason, Monika Jedrzejczak-Czechowicz, Marek L. Kowalski, Andre C. Knulst, Tanya Kralimarkova, Thuy-My Le, Alison Lovegrove, Justin Marsh, Nikolaos G. Papadopoulos, Todor Popov, Nayade del PradoAshok Purohit, Gerald Reese, Isabel Reig, Suranjith L. Seneviratne, Athanasios Sinaniotis, Serge A. Versteeg, Stefan Vieths, Aeilko H. Zwinderman, Clare Mills, Jonas Lidholm, Karin Hoffmann-Sommergruber, Montserrat Fernandez-Rivas, Barbara Ballmer-Weber, Ronald van Ree^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.

Objective: Establishing a molecular map of hazelnut allergy across Europe.

Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.

Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.

Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.

Original language	English
Pages (from-to)	382-391
Number of pages	10
Journal	Journal of Allergy and Clinical Immunology
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.jaci.2014.12.1949
Publication status	Published - Aug 2015

Keywords

EuroPrevall
hazelnut allergy
component-resolved diagnosis
outpatient clinic
LIPID-TRANSFER PROTEIN
CONTROLLED FOOD CHALLENGE
POSITIVE DOUBLE-BLIND
PLANT-DERIVED FOODS
CROSS-REACTIVITY
IGE-BINDING
CORYLUS-AVELLANA
MAJOR ALLERGENS
PEANUT OLEOSIN
IDENTIFICATION

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Datema, M. R., Zuidmeer-Jongejan, L., Asero, R., Barreales, L., Belohlavkova, S., de Blay, F., Bures, P., Clausen, M., Dubakiene, R., Gislason, D., Jedrzejczak-Czechowicz, M., Kowalski, M. L., Knulst, A. C., Kralimarkova, T., Le, T.-M., Lovegrove, A., Marsh, J., Papadopoulos, N. G., Popov, T., ... van Ree, R. (2015). Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. Journal of Allergy and Clinical Immunology, 136(2), 382-391. https://doi.org/10.1016/j.jaci.2014.12.1949

@article{6158e6c87c71462c85cff1d70da56eb5,

title = "Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey",

abstract = "Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.Objective: Establishing a molecular map of hazelnut allergy across Europe.Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.",

keywords = "EuroPrevall, hazelnut allergy, component-resolved diagnosis, outpatient clinic, LIPID-TRANSFER PROTEIN, CONTROLLED FOOD CHALLENGE, POSITIVE DOUBLE-BLIND, PLANT-DERIVED FOODS, CROSS-REACTIVITY, IGE-BINDING, CORYLUS-AVELLANA, MAJOR ALLERGENS, PEANUT OLEOSIN, IDENTIFICATION",

author = "Datema, {Mareen R.} and Laurian Zuidmeer-Jongejan and Riccardo Asero and Laura Barreales and Simona Belohlavkova and {de Blay}, Frederic and Peter Bures and Michael Clausen and Ruta Dubakiene and David Gislason and Monika Jedrzejczak-Czechowicz and Kowalski, {Marek L.} and Knulst, {Andre C.} and Tanya Kralimarkova and Thuy-My Le and Alison Lovegrove and Justin Marsh and Papadopoulos, {Nikolaos G.} and Todor Popov and {del Prado}, Nayade and Ashok Purohit and Gerald Reese and Isabel Reig and Seneviratne, {Suranjith L.} and Athanasios Sinaniotis and Versteeg, {Serge A.} and Stefan Vieths and Zwinderman, {Aeilko H.} and Clare Mills and Jonas Lidholm and Karin Hoffmann-Sommergruber and Montserrat Fernandez-Rivas and Barbara Ballmer-Weber and {van Ree}, Ronald",

year = "2015",

month = aug,

doi = "10.1016/j.jaci.2014.12.1949",

language = "English",

volume = "136",

pages = "382--391",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "2",

}

Datema, MR, Zuidmeer-Jongejan, L, Asero, R, Barreales, L, Belohlavkova, S, de Blay, F, Bures, P, Clausen, M, Dubakiene, R, Gislason, D, Jedrzejczak-Czechowicz, M, Kowalski, ML, Knulst, AC, Kralimarkova, T, Le, T-M, Lovegrove, A, Marsh, J, Papadopoulos, NG, Popov, T, del Prado, N, Purohit, A, Reese, G, Reig, I, Seneviratne, SL, Sinaniotis, A, Versteeg, SA, Vieths, S, Zwinderman, AH, Mills, C, Lidholm, J, Hoffmann-Sommergruber, K, Fernandez-Rivas, M, Ballmer-Weber, B & van Ree, R 2015, 'Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey', Journal of Allergy and Clinical Immunology, vol. 136, no. 2, pp. 382-391. https://doi.org/10.1016/j.jaci.2014.12.1949

TY - JOUR

T1 - Hazelnut allergy across Europe dissected molecularly

T2 - A EuroPrevall outpatient clinic survey

AU - Datema, Mareen R.

AU - Zuidmeer-Jongejan, Laurian

AU - Asero, Riccardo

AU - Barreales, Laura

AU - Belohlavkova, Simona

AU - de Blay, Frederic

AU - Bures, Peter

AU - Clausen, Michael

AU - Dubakiene, Ruta

AU - Gislason, David

AU - Jedrzejczak-Czechowicz, Monika

AU - Kowalski, Marek L.

AU - Knulst, Andre C.

AU - Kralimarkova, Tanya

AU - Le, Thuy-My

AU - Lovegrove, Alison

AU - Marsh, Justin

AU - Papadopoulos, Nikolaos G.

AU - Popov, Todor

AU - del Prado, Nayade

AU - Purohit, Ashok

AU - Reese, Gerald

AU - Reig, Isabel

AU - Seneviratne, Suranjith L.

AU - Sinaniotis, Athanasios

AU - Versteeg, Serge A.

AU - Vieths, Stefan

AU - Zwinderman, Aeilko H.

AU - Mills, Clare

AU - Lidholm, Jonas

AU - Hoffmann-Sommergruber, Karin

AU - Fernandez-Rivas, Montserrat

AU - Ballmer-Weber, Barbara

AU - van Ree, Ronald

PY - 2015/8

Y1 - 2015/8

N2 - Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.Objective: Establishing a molecular map of hazelnut allergy across Europe.Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.

AB - Background: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens.Objective: Establishing a molecular map of hazelnut allergy across Europe.Methods: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.Results: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.Conclusions: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.

KW - EuroPrevall

KW - hazelnut allergy

KW - component-resolved diagnosis

KW - outpatient clinic

KW - LIPID-TRANSFER PROTEIN

KW - CONTROLLED FOOD CHALLENGE

KW - POSITIVE DOUBLE-BLIND

KW - PLANT-DERIVED FOODS

KW - CROSS-REACTIVITY

KW - IGE-BINDING

KW - CORYLUS-AVELLANA

KW - MAJOR ALLERGENS

KW - PEANUT OLEOSIN

KW - IDENTIFICATION

U2 - 10.1016/j.jaci.2014.12.1949

DO - 10.1016/j.jaci.2014.12.1949

M3 - Article

SN - 0091-6749

VL - 136

SP - 382

EP - 391

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 2

ER -

Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Abstract

Keywords

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