Abstract
Haplotype blocks are conceptually defined as genomic segments harbouring sets of coupled polymorphisms that reflect a common ancestral origin. Experimentally, however, haplotype blocks are characterized using computational algorithms based on incomplete inventories of polymorphisms. Haplotype blocks and their deduced strain-distribution patterns are considered to be extremely powerful for use in genetic association and mapping experiments in laboratory mice and rats. However, recent high-density SNP screening in commonly used mouse inbred strains reveals a complex pattern, suggesting that the current expectations for the use of haplotype blocks in genetic mapping will have to be revisited.
| Original language | English |
|---|---|
| Pages (from-to) | 318-322 |
| Number of pages | 5 |
| Journal | Trends in Genetics |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jun 2005 |