TY - JOUR
T1 - Haemostatic changes in urogenital schistosomiasis haematobium
T2 - a case-control study in Gabonese schoolchildren
AU - Mebius, M M
AU - Adegnika, A A
AU - Zinsou, J F
AU - Agobe, J C D
AU - Honkpehedji, Y J
AU - Yazdanbakhsh, M
AU - van Dam, G J
AU - Corstjens, P L A M
AU - Tielens, A G M
AU - de Groot, P G
AU - Urbanus, R T
AU - van Hellemond, J J
PY - 2019/9/10
Y1 - 2019/9/10
N2 - In many tropical areas schistosomiasis is a major health problem causing hepatosplenic, intestinal or urogenital complaints. Hepatosplenic schistosomiasis mansoni is also characterized by blood coagulation abnormalities. Liver pathology plays a role in the development of haemostatic changes and the parasitic infection may directly affect coagulation. However, these contributing factors cannot be studied separately in hepatosplenic schistosomiasis infections. This pilot study provides insight in haemostatic changes in urinary schistosomiasis by studying coagulation parameters in schistosomiasis haematobium-infected Gabonese schoolchildren. Selection on urinary schistosomiasis patients without hepatosplenic complaints allows for the investigation of the direct effects of the parasite on haemostasis. Levels of von Willebrand Factor (VWF) antigen, active VWF and osteoprotegerin were elevated, indicating inflammation-mediated endothelial activation. In contrast to hepatosplenic schistosomiasis, thrombin-antithrombin complex and D-dimer levels were not affected. Despite its small sample size, this study clearly indicates that Schistosoma haematobium directly alters the activation status of the endothelium, without initiation of coagulation.
AB - In many tropical areas schistosomiasis is a major health problem causing hepatosplenic, intestinal or urogenital complaints. Hepatosplenic schistosomiasis mansoni is also characterized by blood coagulation abnormalities. Liver pathology plays a role in the development of haemostatic changes and the parasitic infection may directly affect coagulation. However, these contributing factors cannot be studied separately in hepatosplenic schistosomiasis infections. This pilot study provides insight in haemostatic changes in urinary schistosomiasis by studying coagulation parameters in schistosomiasis haematobium-infected Gabonese schoolchildren. Selection on urinary schistosomiasis patients without hepatosplenic complaints allows for the investigation of the direct effects of the parasite on haemostasis. Levels of von Willebrand Factor (VWF) antigen, active VWF and osteoprotegerin were elevated, indicating inflammation-mediated endothelial activation. In contrast to hepatosplenic schistosomiasis, thrombin-antithrombin complex and D-dimer levels were not affected. Despite its small sample size, this study clearly indicates that Schistosoma haematobium directly alters the activation status of the endothelium, without initiation of coagulation.
KW - endothelial activation
KW - haemostasis
KW - osteoprotegerin
KW - Schistosomiasis haematobium
KW - von Willebrand Factor
KW - Key wordsSchistosomiasis haematobium
UR - http://www.scopus.com/inward/record.url?scp=85072205922&partnerID=8YFLogxK
U2 - 10.1017/S0022149X19000798
DO - 10.1017/S0022149X19000798
M3 - Article
C2 - 31500673
SN - 0022-149X
VL - 94
SP - 1
EP - 6
JO - Journal of helminthology
JF - Journal of helminthology
M1 - e84
ER -