Haemostasis and Parasitic Helminths

Mirjam Mebius

Haemostasis and Parasitic Helminths

Mirjam Mebius

Research output: Thesis › Doctoral thesis 3 (Research UU / Graduation NOT UU)

Abstract

The focus of this thesis is on the interaction of parasitic helminths, in particular schistosomes, with the blood coagulation system of their host. Prolonged presence of the adult schistosome pair in the vasculature is expected to activate the blood coagulation system. The interaction of schistosomes with blood coagulation has been investigated by many other researchers. Also, coagulopathy that is observed after prolonged (hepatosplenic) infection is described in detail.
However, so far a complete overview of the mechanisms schistosomes utilize to interfere with human haemostasis is missing and it is unknown whether there are any yet undiscovered strategies the parasite applies for evading blood coagulation. Furthermore, insights in the presence of coagulopathy in non-hepatosplenic schistosomiasis is currently not available. The aim of the work in this thesis is to
(1) present an overview on the blood coagulation modification mechanisms of schistosomes,
(2) provide insight in coagulopathy in schistosome infections without hepatic disease, and
(3) identify yet unknown mechanisms of modification of blood coagulation by schistosomes and other bloodfeeding parasites.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Mouton, J.W., Supervisor, External person Tielens, A.G.M., Supervisor, External person de Groot, Ph.G., Supervisor van Hellemond, J.J., Co-supervisor, External person Urbanus, Rolf, Co-supervisor
Award date	25 Sept 2019
Publisher	Erasmus University Rotterdam
Print ISBNs	9789463237710
Publication status	Published - 25 Sept 2019
Externally published	Yes

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http://hdl.handle.net/1765/119593

Cite this

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title = "Haemostasis and Parasitic Helminths",

abstract = "The focus of this thesis is on the interaction of parasitic helminths, in particular schistosomes, with the blood coagulation system of their host. Prolonged presence of the adult schistosome pair in the vasculature is expected to activate the blood coagulation system. The interaction of schistosomes with blood coagulation has been investigated by many other researchers. Also, coagulopathy that is observed after prolonged (hepatosplenic) infection is described in detail. However, so far a complete overview of the mechanisms schistosomes utilize to interfere with human haemostasis is missing and it is unknown whether there are any yet undiscovered strategies the parasite applies for evading blood coagulation. Furthermore, insights in the presence of coagulopathy in non-hepatosplenic schistosomiasis is currently not available. The aim of the work in this thesis is to (1) present an overview on the blood coagulation modification mechanisms of schistosomes, (2) provide insight in coagulopathy in schistosome infections without hepatic disease, and (3) identify yet unknown mechanisms of modification of blood coagulation by schistosomes and other bloodfeeding parasites.",

author = "Mirjam Mebius",

year = "2019",

month = sep,

day = "25",

language = "English",

isbn = "9789463237710",

publisher = "Erasmus University Rotterdam",

type = "Doctoral thesis 3 (Research UU / Graduation NOT UU)",

school = "Erasmus University Rotterdam",

}

TY - THES

T1 - Haemostasis and Parasitic Helminths

AU - Mebius, Mirjam

PY - 2019/9/25

Y1 - 2019/9/25

N2 - The focus of this thesis is on the interaction of parasitic helminths, in particular schistosomes, with the blood coagulation system of their host. Prolonged presence of the adult schistosome pair in the vasculature is expected to activate the blood coagulation system. The interaction of schistosomes with blood coagulation has been investigated by many other researchers. Also, coagulopathy that is observed after prolonged (hepatosplenic) infection is described in detail. However, so far a complete overview of the mechanisms schistosomes utilize to interfere with human haemostasis is missing and it is unknown whether there are any yet undiscovered strategies the parasite applies for evading blood coagulation. Furthermore, insights in the presence of coagulopathy in non-hepatosplenic schistosomiasis is currently not available. The aim of the work in this thesis is to (1) present an overview on the blood coagulation modification mechanisms of schistosomes, (2) provide insight in coagulopathy in schistosome infections without hepatic disease, and (3) identify yet unknown mechanisms of modification of blood coagulation by schistosomes and other bloodfeeding parasites.

AB - The focus of this thesis is on the interaction of parasitic helminths, in particular schistosomes, with the blood coagulation system of their host. Prolonged presence of the adult schistosome pair in the vasculature is expected to activate the blood coagulation system. The interaction of schistosomes with blood coagulation has been investigated by many other researchers. Also, coagulopathy that is observed after prolonged (hepatosplenic) infection is described in detail. However, so far a complete overview of the mechanisms schistosomes utilize to interfere with human haemostasis is missing and it is unknown whether there are any yet undiscovered strategies the parasite applies for evading blood coagulation. Furthermore, insights in the presence of coagulopathy in non-hepatosplenic schistosomiasis is currently not available. The aim of the work in this thesis is to (1) present an overview on the blood coagulation modification mechanisms of schistosomes, (2) provide insight in coagulopathy in schistosome infections without hepatic disease, and (3) identify yet unknown mechanisms of modification of blood coagulation by schistosomes and other bloodfeeding parasites.

M3 - Doctoral thesis 3 (Research UU / Graduation NOT UU)

SN - 9789463237710

PB - Erasmus University Rotterdam

ER -

Haemostasis and Parasitic Helminths

Abstract

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