Gut microbiome mediates the protective effects of exercise after myocardial infarction

Qiulian Zhou, Jiali Deng, Xue Pan, Danni Meng, Yujiao Zhu, Yuzheng Bai, Chao Shi, Yi Duan, Tianhui Wang, Xinli Li, Joost Pg Sluijter, Junjie Xiao*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
14 Downloads (Pure)

Abstract

Background: Gut microbiota plays important roles in health maintenance and diseases. Physical exercise has been demonstrated to be able to modulate gut microbiota. However, the potential role of gut microbiome in exercise protection to myocardial infarction (MI) remains unclear. Results: Here, we discovered exercise training ameliorated cardiac dysfunction and changed gut microbial richness and community structure post-MI. Moreover, gut microbiota pre-depletion abolished the protective effects of exercise training in MI mice. Furthermore, mice receiving microbiota transplants from exercised MI mice had better cardiac function compared to mice receiving microbiota transplants from non-exercised MI mice. Mechanistically, we analyzed metabolomics in fecal samples from exercised mice post-MI and identified 3-Hydroxyphenylacetic acid (3-HPA) and 4-Hydroxybenzoic acid (4-HBA), which could be applied individually to protect cardiac dysfunction post-MI and apoptosis through NRF2. Conclusions: Together, our study provides new insights into the role of gut microbiome in exercise protection to MI, offers opportunities to modulate cardiovascular diseases by exercise, microbiome and gut microbiota-derived 3-HPA and 4-HBA. [MediaObject not available: see fulltext.].

Original languageEnglish
Article number82
JournalMicrobiome
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Exercise
  • Gut microbiome
  • Metabolites
  • Myocardial infarction
  • NRF2

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