Guilty as charged: Unmeasured urinary anions in a case of pyroglutamic acidosis

E. J. Rolleman; E. J. Hoorn; P. Didden; R. Zietse

Guilty as charged: Unmeasured urinary anions in a case of pyroglutamic acidosis

E. J. Rolleman, E. J. Hoorn, P. Didden, R. Zietse^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Abstract

A patient developed an unexplained metabolic acidosis with the characteristics of renal tubular acidosis. By correcting the serum anion gap for hypoalbuminaemia and analysing the urinary anions and cations, the presence of unmeasured anions was revealed. The diagnosis of pyroglutamic acidosis, caused by a combination of flucloxacillin and acetaminophen, was established. Strategies for solving complex cases of metabolic acidosis are discussed.

Original language	English
Pages (from-to)	351-353
Number of pages	3
Journal	Netherlands Journal of Medicine
Volume	66
Issue number	8
Publication status	Published - Sept 2008
Externally published	Yes

Keywords

Anion gap
Flucloxacillin
Hypernatraemia
Hypokalaemia
Metabolic acidosis
Urine osmolal gap

Cite this

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abstract = "A patient developed an unexplained metabolic acidosis with the characteristics of renal tubular acidosis. By correcting the serum anion gap for hypoalbuminaemia and analysing the urinary anions and cations, the presence of unmeasured anions was revealed. The diagnosis of pyroglutamic acidosis, caused by a combination of flucloxacillin and acetaminophen, was established. Strategies for solving complex cases of metabolic acidosis are discussed.",

keywords = "Anion gap, Flucloxacillin, Hypernatraemia, Hypokalaemia, Metabolic acidosis, Urine osmolal gap",

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T2 - Unmeasured urinary anions in a case of pyroglutamic acidosis

AU - Rolleman, E. J.

AU - Hoorn, E. J.

AU - Didden, P.

AU - Zietse, R.

PY - 2008/9

Y1 - 2008/9

N2 - A patient developed an unexplained metabolic acidosis with the characteristics of renal tubular acidosis. By correcting the serum anion gap for hypoalbuminaemia and analysing the urinary anions and cations, the presence of unmeasured anions was revealed. The diagnosis of pyroglutamic acidosis, caused by a combination of flucloxacillin and acetaminophen, was established. Strategies for solving complex cases of metabolic acidosis are discussed.

AB - A patient developed an unexplained metabolic acidosis with the characteristics of renal tubular acidosis. By correcting the serum anion gap for hypoalbuminaemia and analysing the urinary anions and cations, the presence of unmeasured anions was revealed. The diagnosis of pyroglutamic acidosis, caused by a combination of flucloxacillin and acetaminophen, was established. Strategies for solving complex cases of metabolic acidosis are discussed.

KW - Anion gap

KW - Flucloxacillin

KW - Hypernatraemia

KW - Hypokalaemia

KW - Metabolic acidosis

KW - Urine osmolal gap

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M3 - Article

C2 - 18809984

AN - SCOPUS:54349115421

SN - 0300-2977

VL - 66

SP - 351

EP - 353

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 8

ER -

Guilty as charged: Unmeasured urinary anions in a case of pyroglutamic acidosis

Abstract

Keywords

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