TY - JOUR
T1 - Growth Hormone Withdrawal in Mid-Puberty
T2 - No Impact on Near Adult Height in Adolescents with Transient Idiopathic GHD
AU - Vliegenthart, Joeri
AU - Wit, Jan M
AU - Bakker, Boudewijn
AU - Boot, Annemieke M
AU - de Bruin, Christiaan
AU - Finken, Martijn J J
AU - van der Heyden, Josine C
AU - Hokken-Koelega, Anita C S
AU - van der Kamp, Hetty J
AU - van Mil, Edgar G
AU - Sas, Theo C J
AU - Schott, Dina A
AU - van Setten, Petra
AU - Straetemans, Saartje
AU - van Tellingen, Vera
AU - Touwslager, Robbert N H
AU - van Trotsenburg, A S Paul
AU - Voorhoeve, Paul G
AU - Rings, Edmond H H M
AU - van den Akker, Erica L T
AU - van der Kaay, Danielle C M
N1 - Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms.
PY - 2026/5
Y1 - 2026/5
N2 - Context: In children with idiopathic isolated growth hormone deficiency (IIGHD), GH secretion often normalizes by near adult height (NAH). Whether recombinant human GH (rhGH) treatment can be safely discontinued earlier remains unclear. Objective: This work aimed to investigate if withdrawing rhGH treatment from mid-puberty onward had no negative effect on attained NAH in adolescents who, after retesting, were no longer GH deficient. Methods: A prospective multicenter patient preference study was conducted at pediatric endocrinology departments in multiple centers (2017-2024) with follow-up until NAH (SEENEZ GH Study). Participants included 127 adolescents (95 male, 75%) with childhood IIGHD (GH peak 1.7-10 µg/L) who tested GH sufficient (GH peak >6.7 µg/L) at mid-puberty. Forty-four continued rhGH (GHcont), 83 discontinued (GHstop). A total of 99% of patients completed the study. Intervention included rhGH treatment continuation vs discontinuation from mid-puberty until NAH. The primary outcome measure was NAH-SDS minus target height (TH)-SDS. The secondary outcome was NAH-SDS, total pubertal growth (TPG), and predicted vs attained height gain. Results: Mean (SD) NAH-SDS minus TH-SDS was −0.17 (0.60) in the GHcont and −0.18 (0.62) in the GHstop group (P = .96). Mean NAH-SDS was −0.91 (0.76) (GHcont) vs −0.78 (0.76) (GHstop) (P = .35). Mean (SD) TPG (from start of puberty) in males was 27.5 cm (7.0; GHcont) vs 25.9 cm (6.2; GHstop) (P = .25) and in females 20.5 cm (5.7; GHcont) vs 20.9 cm (7.6; GHstop) (P = .90). Predicted vs attained height gain based on the prediction model did not differ between groups. Conclusions: In adolescents with transient IIGHD, rhGH treatment can be stopped at mid-puberty. These findings support reducing rhGH treatment duration, lowering patient burden and health-care costs.
AB - Context: In children with idiopathic isolated growth hormone deficiency (IIGHD), GH secretion often normalizes by near adult height (NAH). Whether recombinant human GH (rhGH) treatment can be safely discontinued earlier remains unclear. Objective: This work aimed to investigate if withdrawing rhGH treatment from mid-puberty onward had no negative effect on attained NAH in adolescents who, after retesting, were no longer GH deficient. Methods: A prospective multicenter patient preference study was conducted at pediatric endocrinology departments in multiple centers (2017-2024) with follow-up until NAH (SEENEZ GH Study). Participants included 127 adolescents (95 male, 75%) with childhood IIGHD (GH peak 1.7-10 µg/L) who tested GH sufficient (GH peak >6.7 µg/L) at mid-puberty. Forty-four continued rhGH (GHcont), 83 discontinued (GHstop). A total of 99% of patients completed the study. Intervention included rhGH treatment continuation vs discontinuation from mid-puberty until NAH. The primary outcome measure was NAH-SDS minus target height (TH)-SDS. The secondary outcome was NAH-SDS, total pubertal growth (TPG), and predicted vs attained height gain. Results: Mean (SD) NAH-SDS minus TH-SDS was −0.17 (0.60) in the GHcont and −0.18 (0.62) in the GHstop group (P = .96). Mean NAH-SDS was −0.91 (0.76) (GHcont) vs −0.78 (0.76) (GHstop) (P = .35). Mean (SD) TPG (from start of puberty) in males was 27.5 cm (7.0; GHcont) vs 25.9 cm (6.2; GHstop) (P = .25) and in females 20.5 cm (5.7; GHcont) vs 20.9 cm (7.6; GHstop) (P = .90). Predicted vs attained height gain based on the prediction model did not differ between groups. Conclusions: In adolescents with transient IIGHD, rhGH treatment can be stopped at mid-puberty. These findings support reducing rhGH treatment duration, lowering patient burden and health-care costs.
U2 - 10.1210/clinem/dgaf626
DO - 10.1210/clinem/dgaf626
M3 - Article
C2 - 41239863
SN - 0021-972X
VL - 111
SP - 1319
EP - 1328
JO - The Journal of clinical endocrinology and metabolism
JF - The Journal of clinical endocrinology and metabolism
IS - 5
ER -