TY - JOUR
T1 - Group a rotavirus surveillance before vaccine introduction in italy, september 2014 to august 2017
AU - Ianiro, Giovanni
AU - Micolano, Roberto
AU - Di Bartolo, Ilaria
AU - Scavia, Gaia
AU - Monini, Marina
AU - Pagani, Elisabetta
AU - Moroder, Ludwig
AU - Aschbacher, Richard
AU - Binda, Sandro
AU - Pellegrinelli, Laura
AU - Farina, Claudio
AU - Mignacca, Anna
AU - Bruno, Rosella
AU - Vuolo, Assunta
AU - Peyronel, Elvio
AU - Contarini, Maria Natalia
AU - Zanella, Francesca
AU - Bordignon, Graziano
AU - Zoppelletto, Maira
AU - Affanni, Paola
AU - Lazzarotto, Tiziana
AU - Chiereghin, Angela
AU - Recanatini, Claudia
AU - D’Errico, Marcello
AU - Camilloni, Barbara
AU - Concato, Carlo
AU - Onori, Manuela
AU - Valentini, Diletta
AU - Campagnuolo, Rosalba
AU - Mungiguerra, Maria
AU - Chironna, Maria
AU - Morea, Anna
AU - Castiglia, Paolo
N1 - Funding Information:
Funding: This study was supported by EuroRotaNet ( www. eurorota.net ).
Publisher Copyright:
© 2019, European Centre for Disease Prevention and Control (ECDC). All right reserved.
PY - 2019/4/11
Y1 - 2019/4/11
N2 - Introduction: Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young children, causing ca 250,000 deaths worldwide, mainly in lowincome countries. Two proteins, VP7 (glycoprotein, G genotype) and VP4 (protease-sensitive protein, P genotype), are the basis for the binary RVA nomenclature. Although 36 G types and 51 P types are presently known, most RVA infections in humans worldwide are related to five G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], G9P[8]. Aim: This study aimed to characterise the RVA strains circulating in Italy in the pre-vaccination era, to define the trends of circulation of genotypes in the Italian paediatric population. Methods: Between September 2014 and August 2017, after routine screening in hospital by commercial antigen detection kit, 2,202 rotavirus-positive samples were collected in Italy from children hospitalised with AGE; the viruses were genotyped following standard European protocols. Results: This 3-year study revealed an overall predominance of the G12P[8] genotype (544 of 2,202 cases; 24.70%), followed by G9P[8] (535/2,202; 24.30%), G1P[8] (459/2,202; 20.84%) and G4P[8] (371/2,202; 16.85%). G2P[4] and G3P[8] genotypes were detected at low rates (3.32% and 3.09%, respectively). Mixed infections accounted for 6.49% of cases (143/2,202), uncommon RVA strains for 0.41% of cases (9/2,202). Conclusions: The emergence of G12P[8] rotavirus in Italy, as in other countries, marks this genotype as the sixth most common human genotype. Continuous surveillance of RVA strains and monitoring of circulating genotypes are important for a better understanding of rotavirus evolution and genotype distribution, particularly regarding strains that may emerge from reassortment events.
AB - Introduction: Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young children, causing ca 250,000 deaths worldwide, mainly in lowincome countries. Two proteins, VP7 (glycoprotein, G genotype) and VP4 (protease-sensitive protein, P genotype), are the basis for the binary RVA nomenclature. Although 36 G types and 51 P types are presently known, most RVA infections in humans worldwide are related to five G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], G9P[8]. Aim: This study aimed to characterise the RVA strains circulating in Italy in the pre-vaccination era, to define the trends of circulation of genotypes in the Italian paediatric population. Methods: Between September 2014 and August 2017, after routine screening in hospital by commercial antigen detection kit, 2,202 rotavirus-positive samples were collected in Italy from children hospitalised with AGE; the viruses were genotyped following standard European protocols. Results: This 3-year study revealed an overall predominance of the G12P[8] genotype (544 of 2,202 cases; 24.70%), followed by G9P[8] (535/2,202; 24.30%), G1P[8] (459/2,202; 20.84%) and G4P[8] (371/2,202; 16.85%). G2P[4] and G3P[8] genotypes were detected at low rates (3.32% and 3.09%, respectively). Mixed infections accounted for 6.49% of cases (143/2,202), uncommon RVA strains for 0.41% of cases (9/2,202). Conclusions: The emergence of G12P[8] rotavirus in Italy, as in other countries, marks this genotype as the sixth most common human genotype. Continuous surveillance of RVA strains and monitoring of circulating genotypes are important for a better understanding of rotavirus evolution and genotype distribution, particularly regarding strains that may emerge from reassortment events.
UR - http://www.scopus.com/inward/record.url?scp=85064966117&partnerID=8YFLogxK
U2 - 10.2807/1560-7917.ES.2019.24.15.1800418
DO - 10.2807/1560-7917.ES.2019.24.15.1800418
M3 - Article
C2 - 30994104
AN - SCOPUS:85064966117
SN - 1025-496X
VL - 24
JO - Eurosurveillance
JF - Eurosurveillance
IS - 15
M1 - 1800418
ER -